INTRODUCTION
Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.
MANUFACTURE
- Plant Source: Primarily obtained from Colchicum autumnale corms and seeds.
- Extraction Process: Plant material is dried and powdered. Extracted with acidified water or alcohol (e.g., ethanol or methanol). Colchicine is then isolated by solvent extraction, followed by purification via crystallization.
- Purification: May involve chromatographic techniques/solvent partitioning to improve purity.
| Synonym | N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo [a]heptalen-7-yl)acetamide |
| CAS no. | 64-86-8 |
| EINECS no. | 200-598-5 |
| Molecular formula | C₂₂H₂₅NO₆ |
| Molecular weight | 399.44 |
| Structure |  |
APPLICATIONS
| Medical Applications: |
| • Gout Treatment |
| Used to relieve acute gout attacks by reducing inflammation and crystal-induced joint damage. |
| Acts by inhibiting neutrophil activity and microtubule polymerization. |
| • Familial Mediterranean Fever (FMF) |
| Colchicine is the first-line treatment to prevent and reduce flare-ups. |
| • Pericarditis |
| Used as an adjunct therapy to reduce recurrence in pericardial inflammation. |
| • Behçet’s Disease |
| Sometimes used for mucocutaneous and articular symptoms. |
| • Anti-mitotic Agent |
| Prevents spindle formation in dividing cells, thus used experimentally in cancer and cytogenetic research. |
| Research and Laboratory Applications: |
| • Mitotic Inhibitor |
| Blocks cell division at metaphase, useful in preparing karyotypes for chromosome analysis. |
| • Plant Breeding |
| Induces polyploidy (chromosome doubling) in plants to create new crop varieties with improved traits. |
SPECIFICATIONS – Ph.Eur/BP
| Test | Unit | Specification |
|---|---|---|
| Description | – | Yellowish-white amorphous or crystalline powder |
| Solubility | – | Very soluble in water, rapidly recrystallizing from concentrated solutions as the sesquihydrate, freely soluble in alcohol, practically insoluble in cyclohexane. |
| Identification | – | Should conform to IR Spectrophotometry |
| Appearance of solution | – | Solution S should be clear and not more intensely colored than reference solution GY |
| Acidity or Alkalinity | – | Should comply |
| Specific optical rotation | ° | -235 to -250 (anhydrous substance) |
| Related substance | ||
| Impurity A | % | NMT 3.5 |
| Impurity B | % | NMT 1.0 |
| Impurity C | % | NMT 1.0 |
| Impurity D | % | NMT 1.0 |
| Impurity E | % | NMT 1.0 |
| Unspecified impurities | % | NMT 0.1 |
| Total impurities | % | NMT 5.0 |
| Colchicine | % | NMT 0.2 |
| Chloroform | ppm | NMT 500 |
| Ethyl acetate | % | NMT 6.0 |
| Water content | % | NMT 2.0 |
| Sulphated ash | % | NMT 0.1 |
| Assay (anhydrous substance) | % | 97.0 to 102.0 |
| Additional test | ||
| Residual solvents | ||
| Methanol | ppm | NMT 3000 |
| Ethyl alcohol | ppm | NMT 5000 |
| Dichloromethane | ppm | NMT 600 |
| Benzene | ppm | NMT 2 |
PACKING
25 kg UN approved drum with inner packing 1 kg.
STORAGE
WHO-GMP, Written Confirmation (WC) and DMF.
CERTIFICATION
WHO-GMP, Written Confirmation (WC) and DMF.
ExSyn offers Colchicine on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Dibutyl sulfide is an organosulfur. It is a clear, colorless to pale yellow liquid characterized by a strong sulfur-like odor and is primarily used as an intermediate in chemical synthesis, specialty organic manufacturing, and research applications. The compound exhibits good solvency properties and moderate thermal stability, making it useful in industrial and laboratory processes involving sulfur-containing organic compounds.
Oleylamine is a long-chain (C18) primary fatty amine derived from natural fatty acids, typically sourced from vegetable oils. It is produced from oleic acid through conversion of the carboxylic acid group (–COOH) into an amine group (–NH₂). With its optimal balance of hydrophobic chain length and reactive amine functionality it serves as a versatile and dependable building block for high-performance formulations.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
Pyrazinamide is a first-line antitubercular drug used in combination therapy for the treatment of tuberculosis (TB). It is a synthetic pyrazine derivative and acts as a prodrug, which is converted into its active form (pyrazinoic acid) inside Mycobacterium tuberculosis.
6-Bromopyridine-2,3-diamine is a heterocyclic organic compound belonging to the class of substituted pyridines. It is used mainly as an intermediate in pharmaceuticals and agrochemicals.
Magnesium trisilicate is an inorganic compound commonly used in pharmaceutical and gastrointestinal (GI) preparations due to its dual action. It is usually produced as a white, odorless, fine powder. It helps bind toxins or irritants in the gastrointestinal tract and occasionally used in formulations for its stabilizing properties.
Choline salicylate is a salicylate salt formed from choline and salicylic acid. It is a non-steroidal anti-inflammatory agent (NSAID-type compound) mainly used for its analgesic, anti-inflammatory, and mild antiseptic properties. Unlike acetylated salicylates, it is less irritating to the gastric mucosa and is commonly used in topical oral preparations such as gels and mouth paints.
TensyraTM N-10 (Octoxinol 10; tert-octyl phenyl ethoxylate) is a non-ionic surfactant known for its excellent solubilizing and membrane-permeabilizing properties. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.It readily breaks down biological membranes to lyse cells, solubilize proteins, and permeabilize cell membranes for assays.
Teprenone (Geranylgeranylacetone, GGA) is a mixture of the all-trans and mono-cis isomers of 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one (in a weight ratio of 3:2). It is an acyclic isoprenoid compound with a structure like retinoids and is widely used for the treatment of gastrointestinal ulcers.