INTRODUCTION
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
MANUFACTURE
2-Chloro-1,1,1-trimethoxyethane is typically manufactured through the reaction of chloroacetaldehyde derivatives or chlorinated acetals with methanol under acidic catalytic conditions, resulting in the formation of the corresponding trimethoxy orthoester. The process is conducted under controlled temperature and moisture-free conditions to maximize product purity and minimize hydrolysis of the orthoester functionality.
| Synonyms | 1,1,1-Trimethoxy-2-chloroethane, 2-chloro-1,1,1-trimethoxyethane |
| CAS no. | 74974-54-2 |
| EINECS no. | 629-378-0 |
| Molecular formula | C₅H₁₁ClO₃ |
| Molecular weight | 154.59 g/mol |
| Structure |  |
APPLICATIONS
Chemical intermediate in the synthesis of:
| Intermediate for the synthesis of pharmaceutical compounds and drug candidates. |
| Preparation of heterocyclic compounds such as oxadiazoles and quinazolinones. |
| Used in synthesis of Agrochemicals. |
| Specialty chemical synthesis. |
| Chloromethylating building block in organic synthesis. |
| Research and development involving fine chemicals and advanced intermediates |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Colorless lo yellow liquid |
| Identification by IR | – | Conforms to structure |
| Water Content by KF | (%w/v) | NMT 0.5 |
| Purity by GC | % | NMT 97 |
| Deschloro Impurity | % | NMT 0.5 |
| Any Unspecified Impurities | % | NMT 1.0 |
| Total Impurities | % | NMT 3.0 |
PACKING
Compliant with international regulations
STORAGE
Store the product in tightly sealed containers in a cool, dry, and well-ventilated area away from heat, sparks, open flames, and moisture. Recommended storage temperatures are typically 2–8°C or refrigerated conditions. Containers should be protected from direct sunlight and exposure to water, as orthoesters may hydrolyze in the presence of moisture.
REACH status
Not registered
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2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.