INTRODUCTION
1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.
Manufacture
1-Butylimidazole is industrially synthesized through the alkylation of imidazole with a butyl halide (like 1-chlorobutane) or butyl iodide, often in the presence of a base such as sodium hydroxide, potassium hydroxide, or other suitable inorganic or organic bases leading to deprotonation of imidazole. The crude product is further purified by distillation.
| Synonyms | 1-Butyl-1H-imidazole |
| CAS no. | 4316-42-1 |
| EINECS no. | 224-335-9 |
| Molecular formula | C7H12N2 |
| Molecular weight | 124.18 |
| Structure |  |
Applications
An important intermediate in the synthesis of various chemical compounds, including ionic liquids and other pharmaceuticals, it is also used as a ligand in coordination chemistry and in the synthesis of materials for chiral separation.
| Chemical Intermediate |
| As a building block for Imidazole derivatives |
| Used as a starting material to prepare 1-butyl-3- substituted imidazolium salts. |
| Ionic Liquid Synthesis |
| As a building blocks of ionic liquids, which have wide industrial and research applications. |
| Catalysis & Ligand Chemistry |
| 1-Butylimidazole and its salts are explored in : |
| Homogeneous catalysis |
| Organocatalysis (via N-heterocyclic carbene precursors) |
| Phase-transfer catalysis |
| Pharmaceutical & Material Science Research |
| 1-Butylimidazole is a precursor for synthesizing various active ingredients in antiviral drugs |
| Solvent & Reaction Medium |
| Its salt derivatives are used as green solvents (ionic liquid form) for organic synthesis, polymerization, and biomass processing. |
| As electrolytes in batteries, fuel cells, and supercapacitors |
| Agrochemicals |
| Used as a building block for active ingredients in fungicides and herbicides. |
| Materials Science |
| It acts as a curing agent for epoxy resins, improving their mechanical properties, chemical resistance, and adhesion in coatings, adhesives, and composites |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Colourless to pale yellow liquid |
| Identification (By GC) | – | Should conform to the standard |
| Water Content | % | Max 1.0 |
| Purity (By GC) | % Area | Min 99.0 |
| Any single Impurity | % | NMT 0.5 |
STORAGE & PRECAUTION
Store at ambient conditions
PACKING
25 kg HDPE UN approved drum.
REACH Status
Not registered
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