INTRODUCTION
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
MANUFACTURE
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide generally prepared by quaternization (alkylation) of triphenylphosphine with methyl 2-bromopropanoate under controlled reaction conditions.
| Synonyms | Phosphonium, (1-carboxyethyl)triphenyl-, bromide, methyl ester; (1-Carboxyethyl)triphenylphosphonium bromide, methyl ester |
| CAS no. | 2689-62-5 |
| EINECS no. | N/A |
| Molecular formula | C22H22BrO2P |
| Molecular weight | 429.29 |
| Structure |  |
APPLICATIONS
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is mainly used for preparing stabilized phosphorus ylides, which are important reagents in olefination reactions. The main areas of application include:
| Organic synthesis |
|---|
| Produces stabilized ylide with good selectivity. |
| The ylide is used in synthesis of α, β-unsaturated esters, Conjugated dienes, Functionalized alkenes, etc. |
| Pharmaceutical intermediates |
|---|
| It serves as a key intermediate in synthesizing: 1. Drug candidates, 2. Biologically active molecules, 3. Natural product analogues, etc. |
| Fine chemical manufacturing |
|---|
| The reagent is used in producing: 1. Specialty chemicals, 2. Functional intermediates, 3. Custom synthesis products, etc. |
| Agrochemical synthesis |
|---|
| Used in preparing intermediates for: 1. Herbicides, 2. Fungicides, 3. Insecticides, etc. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off-white crystalline powder |
| Identification by 1H and 31P NMR | – | Conform to the structure |
| Purity (by HPLC) | % | NLT 97.0 |
| Water content | % | NMT 1.0 |
| Free triphenylphosphine | % | NMT 1.0 |
| Triphenylphosphine oxide | % | NMT 1.0 |
STORAGE & PRECAUTION
Store the container tightly closed in a dry, cool and well-ventilated place.
PACKING
25 kg UN approved drum
REACH Status
Not registered
ExSyn offers (2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide on a commercial scale and welcomes your enquiries. Regardless of the quantity required, our commitment to exceptional quality and reliable service makes ExSyn the preferred supplier of choice! Should you require any additional information or SDS, please feel free to contact us.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.