INTRODUCTION
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane. Due to its bifunctional reactivity, glycolaldehyde dimer serves as a valuable intermediate in organic synthesis and various industrial applications. It serves as a convenient precursor wherever glycolaldehyde reactivity is needed.
MANUFACTURE
Glycolaldehyde dimer is generally produced through the controlled oxidation of ethylene glycol or through catalytic processes involving formaldehyde-derived intermediates. The resulting glycolaldehyde monomers spontaneously dimerize during isolation and crystallization, yielding the more dimeric product. Purification is typically achieved through crystallization.
| Synonyms | 2,5-Dihydroxy-1,4-dioxane, Glycerol aldehyde dimer, 2,5-Dihydroxy-p-dioxane p-Dioxane-2,5-diol |
| CAS no. | 23147-58-2 |
| EINECS no. | 607-202-3 |
| Molecular formula | C4H8O4 |
| Molecular weight | 120.10 |
| Structure |  |
APPLICATIONS
Glycolaldehyde dimer is valued because under process conditions it serve as a source of highly reactive monomeric glycolaldehyde. The main areas of application include:
| Pharmaceutical Industry: |
|---|
| Intermediate in the synthesis of pharmaceutical intermediates. |
| Building block for the preparation of heterocyclic compounds and specialty molecules. |
| Fine Chemicals and Organic Synthesis: |
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| Versatile C2 synthon for carbon-carbon bond-forming reactions. |
| Used in the synthesis of carbohydrates, amino alcohols, and other functionalized organic compounds. |
| Polymer and Resin Industry: |
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| Crosslinking and chain-extension agent in specialty polymer formulations. |
| Intermediate for the preparation of advanced materials and functional resins. |
| Research and Biotechnology: |
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| Utilized in studies related to prebiotic chemistry and carbohydrate formation. |
| Reagent for biochemical and synthetic chemistry research applications. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White solid mass |
| Melting Point | °C | Min 80.0 |
| Assay (by GC) | % | Min 98.0 |
STORAGE & PRECAUTION
Keep container tightly closed at 2-8 °C for short-term storage or below −20 °C for extended storage.
PACKING
30 kg / 250 kg UN Approved drums.
REACH Status
Not registered
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