INTRODUCTION

2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.

Manufacture

The synthesis method of 2-chloroethylamine hydrochloride mainly comprises a synthesis method of ethanolamine hydrochloride and thionyl chloride and a synthesis method of ethanolamine and hydrogen chloride.

Synonym2-Aminoethyl chloride hydrochloride
CAS no.870-24-6
EINECS no.212-793-2
Molecular formulaC2H7Cl2N
Molecular weight115.99
Structure
APPLICATIONS
Used as an intermediate in APIs
* Ifosfamide – cytotoxic, antineoplastic
* Fluvoxamine maleate – antidepressant
Used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs.
Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.
Further, it is employed as a derivatizing reagent for amino acids, dipeptides and nucleotides.

SPECIFICATIONS

TestUnitSpecification
DescriptionWhite to off white powder
SolubilitySoluble in wáter and methanol
Identification (by IR)IR spectrum of the sample should correspond
to that of the standard
Water content% w/wNMT 1.0
Ionic Chloride% w/w29.0 – 32.1
Assay (by Titrimetry
– on anhydrous basis)
% w/w98.0 – 102.0
Note: Material is highly hygroscopic, and it should be opened under nitrogen atmosphere only

PACKING
25 kg UN approved HDPE bag/drum.

STORAGE
Store in original container, protected from light and heat.

REACH Status
Not registered yet.

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