INTRODUCTION
Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.
Manufacture
It is manufactured by two step process. In the first one, carbon disulphide reacts with chlorine to form an intermediate. In the second step, the intermediate is reduced to form thiophosgene.
| Synonyms | Thiocarbonyl chloride Carbon chlorosulphide |
| CAS no. | 463-71-8 |
| EINECS no. | 207-341-6 |
| Molecular formula | CSCl2 |
| Molecular weight | 114.98 |
| Structure |  |
Applications
| APIs – Thiophosgene is used in production of |
|---|
| Amoscanate, an anthelmintic drug |
| Intermediates – It also finds uses in production of a range of intermediates such as |
|---|
| Di-2-pyridyl thiocarbonate |
| 2-Ethoxyphenyl isocyanate |
| 3-Isothiocyanato-1,5-dimethyl-1H-pyrazole |
| 5-Bromo-6-isocyanate quinoxaline |
| Agrochemicals |
|---|
| Butyletherurea, and acaricide |
| in production of many insecticides and pesticides |
| Others |
|---|
| In anaerobic oxidation of alcohols to produce aldehydes and ketones |
| In production of isothiocyanates from primary amines |
| In synthesis of alkanes from 1,3-diols |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Red, burgundy coloured liquid |
| Density | gm/ml | 1.45 – 1.50 |
| Boiling range | °C | 70 – 75 |
| Purity by GC | % | Min 90.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 kg UN approved drum.
REACH Status
Not registered yet.
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