INTRODUCTION
The heterocyclic is a liquid that serves as one of main coupling agents in the peptides and polypeptides production. The molecule is already activated by the presence of the aldehyde group and hence reacts readily in number of reactions.
| Synonyms | Nicotinaldehyde, Pyridine-3-Carbaldhyde |
| CAS no. | 500-22-1 |
| EINECS no. | 207-900-4 |
| Molecular formula | C6H5NO |
| Structure | (download pdf to view) |
| Molecular weight | 107.11 |
APPLICATIONS
This compound finds wide applications across various industry segments.
Peptides and Polypeptides
As a KRM for peptides and coupling agent for a broad spectrum of polypeptides manufactured by solid state synthesis. These include Abarelix, Cetroreix and Ganirelix.
Pharmaceuticals
Pyridine-3-carboxaldehyde serves as a building block in synthesis of number of APIs such as antiretroviral protease inhibitor used in the battle against HIV, glycoprotein antagonist, etc.
| API | Therapeutic Category |
| Indinavir | Anti-retroviral |
| Elarofiban | Thrombosis management |
| Seletalisib | Immunomodulator |
| Xanomeline Oxalate | CNS |
| Paroxetine HCl | CNS |
Agrochemicals
The compound is also a KRM in manufacture of:
a) Pymetrozine, an insecticide and a xenobiotic
b) Pyrifenox, a fungicide
Intermediates
A series of value-added intermediates can also be synthesized by using nicotinaldehyde.
These include:
a) Pyridin-3-yl-methylhydrazine
b) 3-(Pyridin-3-yl)propanal
c) (S)-N- Boc -(3pyridyl)alanine
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Pale yellow to brown liquid |
| Identification By GC | – | The retention time of the major peak of sample corresponds to that of standard |
| Purity By GC | % | NLT 98.0 |
STORAGE
The product is stored at ambient temperature.
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