INTRODUCTION
The fused heterocyclic formed by fusion of pyrimidine and pyrrole rings, is a solid compound with a chromatographic purity of 98%.
It displays keto and enol isomers as is reflected in its synonyms and is an important biochemical reagent and a vital nucleobase.
| Synonyms | 3,7-Dihydro pyrrole[2,3] pyrimidine-4-one Pyrrolo [2,3-d]pyrimidin-4-ol 7H-Pyrrolo[2,3-d]pyrimidin-4-ol |
| CAS no. | 3680-71-5 |
| EINECS no. | 640-613-6 |
| Molecular formula | C6H5N3O |
| Structure | (download pdf to view) |
| Molecular weight | 135.12 |
APPLICATIONS
The product as such has medicinal properties and its therapeutic use is cited as prodrug of thymidine phosphorylase inhibitor. Besides, it also finds use as a building block in the synthesis of API’s such as:
| API | THERAPEUTIC CATEGORY |
| Clofarabine | Anti-neoplastic, Anti-cancer |
| Ruxolitinib | Anti-cancer |
| Tofacitinib | Anti-cancer |
| Baricitinib | Anti-cancer |
It is also used in the manufacture of a series of value-added intermediates such as:
| INTERMEDIATE | CAS# |
| 4-Chloropyrrolo[2,3-d]pyrimidine | 3680-69-1 |
| 1,7-Dihydropyrrolo[2,3-d]pyrimidine-4-thione | 1421-27-8 |
| 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine | 941685-26-3 |
| 4-chloro-7-(phenylsulfonyl)-7h-pyrrolo[2,3-d]-Pyrimidine | 186519-89-1 |
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | White to Brown Solid |
| Identification | ||
| a. 1H NMR | – | Conforms to the structure |
| b. LCMS | – | Conforms to the structure |
| c. FTIR | – | Conforms to the structure |
| Purity by HPLC | % | NLT 98 |
| Moisture | Wt. % | NMT 0.5 |
| Largest unspecified impurity | % | NMT 0.5 |
STORAGE
The product is stored at ambient temperature.
ExSyn offers this compound on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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