INTRODUCTION
Guanosine 5’-diphosphate disodium salt (GDP·Na2) is a purine nucleoside diphosphate that plays a crucial role in various biochemical processes. It is a nucleoside consisting of the base guanine and the sugar ribose
It has two phosphate groups, which affects its function and interactions with enzymes. It is a salt form where two sodium ions are associated with the GDP molecule to make it soluble in water
It is widely used in molecular biology, pharmacology and other scientific research
Manufacture
Guanosine 5′-diphosphate disodium salt can be synthesized by synthetic route which involves phosphorylation of guanosine using phosphoric acid derivatives in presence of catalyst
| Synonym | ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate, disodium salt |
| CAS # | 7415-69-2 |
| EINECS # | 231-026-2 |
| Molecular formula | C10H13N5Na2O11P2 |
| Molecular weight | 487.16 |
| Structure |  |
| Applications |
|---|
| Guanosine 5’-diphosphate disodium salt is widely used in scientific research due to its role in cellular processes. Some of its applications include: |
| Chemistry Research |
|---|
| GDP·Na2is used as a substrate in enzymatic reactions to study enzyme kinetics and mechanisms |
| Molecular Biology |
|---|
| GDP·Na2 is a kind of research reagent, widely used in molecular biology, pharmacology and other scientific research |
| It is used to study cell signaling processes mediated by guanine nucleotide exchange factors |
| GDP·Na2 is a substrate for pyruvate kinase, capable of producing GTP for RNA biosynthesis |
| GDP·Na2 is used to study the characteristics and kinetics of GTPases, such as G-protein-coupled receptors (GPCR) |
| Medicinal Research |
|---|
| It is being investigated for its potential role in neurological disorders and as a therapeutic agent |
| Industrial Application |
|---|
| Utilized in the production of nucleic acid-based products |
| Participates in oxidation-reduction substitution reactions where Phosphates group are replaced by other functional groups. e.g., formation of Guanosine 5’-triphosphate & reduction to Guanosine monophosphate |
| Used as biochemical reagent |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Description | – | White or almost white crystalline powder |
| Identification | – | Should have the largest absorption at 256 ±2nm wavelength. |
| – | A250/A260: 090 ~ 100 | |
| A280/A260: 0.62 -0.72 | ||
| – | Dissolve in dilute nitric acid, add Ammonium molybdate TS. Heat for a few minutes and cool, a yellow precipitate should be produced. | |
| – | Should yield the flame reactions characteristic of sodium salts | |
| Loss on drying | % | < 15.0 |
| Protein | – | No turbidity should be produced |
| Heavy Metals | % | ≤ 0.001 |
| Purity (By HPLC) | % | > 90.0 |
| Content (on dry basis) | % | > 85.0 |
PACKING
HDPE drums
STORAGE
Recommended storage temperature is -20 °C
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