INTRODUCTION
Iodomethane-d3, also known as methyl iodide-d3, is a deuterium-enriched analogue of iodomethane, where the standard hydrogen atoms are substituted with deuterium. This isotopically labelled compound plays a crucial role in research and development, particularly in the pharmaceutical, agrochemical, and labelling studies.
MANUFACTURE
The process involves refluxing deuterated methanol with red phosphorus and iodine in diethyl ether, where phosphorus triiodide forms and reacts with CD3OH to produce Iodomethane-d3
| Synonym | Methyl-d3 Iodide, Deuterated iodomethane |
| CAS no. | 865-50-9 |
| EINECS no. | 212-744-5 |
| Molecular formula | CD3I |
| Molecular weight | 144.96 |
| Structure |  |
APPLICATIONS
| • It is used in the synthesis of labeled compounds to track and study metabolic pathways, drug interactions, and distribution within biological systems |
| • It serves as a crucial building block for synthesizing labeled drug molecules, especially in pharmacokinetic studies |
| • Useful for elucidating reaction mechanisms in organic chemistry by providing insights into the roles of isotopic labels |
| • Facilitates the development and monitoring of new pesticides, herbicides, and fungicides, particularly in analyzing their environmental behavior and degradation |
| • Serves as a tracer in environmental research to investigate the distribution and behavior of chemicals in different environmental compartments |
| • It enhances the resolution of NMR spectroscopy for structural elucidation and dynamic studies of molecules by reducing the complexity of spectral data due to the presence of deuterium. |
| • It is used in forensic science to trace and identify substances by analyzing their isotopic signatures |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Colorless to light red liquid |
| Identification by 2H NMR | – | Should confirm to the structure |
| Isotopic Enrichment by 1H NMR | % | ≥ 99.5 |
| Assay by GC | % | ≥ 98.0 |
STORAGE
Keep container tightly closed in a dry, dark and cool place, away from light
PACKING
25 kg stainless steel containers
REACH Status
Not registered
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