INTRODUCTION
Guanosine 5’-diphosphate disodium salt (GDP·Na2) is a purine nucleoside diphosphate that plays a crucial role in various biochemical processes. It is a nucleoside consisting of the base guanine and the sugar ribose
It has two phosphate groups, which affects its function and interactions with enzymes. It is a salt form where two sodium ions are associated with the GDP molecule to make it soluble in water
It is widely used in molecular biology, pharmacology and other scientific research
Manufacture
Guanosine 5′-diphosphate disodium salt can be synthesized by synthetic route which involves phosphorylation of guanosine using phosphoric acid derivatives in presence of catalyst
| Synonym | ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate, disodium salt |
| CAS # | 7415-69-2 |
| EINECS # | 231-026-2 |
| Molecular formula | C10H13N5Na2O11P2 |
| Molecular weight | 487.16 |
| Structure |  |
| Applications |
|---|
| Guanosine 5’-diphosphate disodium salt is widely used in scientific research due to its role in cellular processes. Some of its applications include: |
| Chemistry Research |
|---|
| GDP·Na2is used as a substrate in enzymatic reactions to study enzyme kinetics and mechanisms |
| Molecular Biology |
|---|
| GDP·Na2 is a kind of research reagent, widely used in molecular biology, pharmacology and other scientific research |
| It is used to study cell signaling processes mediated by guanine nucleotide exchange factors |
| GDP·Na2 is a substrate for pyruvate kinase, capable of producing GTP for RNA biosynthesis |
| GDP·Na2 is used to study the characteristics and kinetics of GTPases, such as G-protein-coupled receptors (GPCR) |
| Medicinal Research |
|---|
| It is being investigated for its potential role in neurological disorders and as a therapeutic agent |
| Industrial Application |
|---|
| Utilized in the production of nucleic acid-based products |
| Participates in oxidation-reduction substitution reactions where Phosphates group are replaced by other functional groups. e.g., formation of Guanosine 5’-triphosphate & reduction to Guanosine monophosphate |
| Used as biochemical reagent |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Description | – | White or almost white crystalline powder |
| Identification | – | Should have the largest absorption at 256 ±2nm wavelength. |
| – | A250/A260: 090 ~ 100 | |
| A280/A260: 0.62 -0.72 | ||
| – | Dissolve in dilute nitric acid, add Ammonium molybdate TS. Heat for a few minutes and cool, a yellow precipitate should be produced. | |
| – | Should yield the flame reactions characteristic of sodium salts | |
| Loss on drying | % | < 15.0 |
| Protein | – | No turbidity should be produced |
| Heavy Metals | % | ≤ 0.001 |
| Purity (By HPLC) | % | > 90.0 |
| Content (on dry basis) | % | > 85.0 |
PACKING
HDPE drums
STORAGE
Recommended storage temperature is -20 °C
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.