INTRODUCTION
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
MANUFACTURE:
It is typically produced through microbial fermentation using strains such as Streptococcus, followed by a series of purification steps including filtration, precipitation, and drying to yield a high-purity, stable powder form suitable for various applications.
| Synonyms | hyaluronic acid sodium salt, sodium hyaluronate, hyaluronan sodium, and HA sodium salt. |
| CAS no. | 9067-32-7 |
| EINECS no. | 618-620-0 |
| Molecular formula | (C14H20NNaO11)n |
| Molecular weight | 403.32 |
| Structure |  |
APPLICATIONS
| Ophthalmic solutions |
| It is used as an aid in ophthalmic surgery. |
| Osteoarthritis injections. |
| Cosmetics (as a hydrating and anti-aging ingredient. |
| Medical devices (including dermal fillers and wound healing formulations) |
| Advanced Delivery Systems :Encapsulated sodium hyaluronate provides controlled release mechanisms. |
| Pharmaceuticals : In topical preparations it functions like a nanocarrier. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White or almost white, powder or fibrous aggregate |
| Identification | ||
| Appearance of solution | – – | Should be Clear A 600nm ≤ 0.01 |
| Reaction (a) of Sodium | – | Should give positive reaction |
| pH | – | 5.0-8.5 |
| Loss on drying | % | NMT 20 |
| Intrinsic Viscosity | m3/kg | 1.2 – 2.8 |
| Nucleic acids | A260 nm | < 0.5 |
| Protein | % | NMT 0.1% |
| Chlorides | % | NMT 0.5 |
| Iron | ppm | NMT 30 |
| Microbial contamination (TAMC) | cfu /g | NMT 100 |
| Bacterial endotoxins | IU/mg | NMT 0.5 |
| Assay (On dried basis) | % | 95.0 – 105.0 |
| Residual Solvents (Additional In-house Test) | ||
| Ethanol | ppm | NMT 5000 |
PACKING
100 g bottles for smaller quantities, 25 kg drums and 200 kg drums for commercial quantities.
STORAGE
Store in airtight container, protected from light and humidity between 2-8°C
REACH status
Not registered
ExSyn offers Sodium Hyaluronate Ph. Eur. on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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