INTRODUCTION
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
MANUFACTURE:
It is typically produced through microbial fermentation using strains such as Streptococcus, followed by a series of purification steps including filtration, precipitation, and drying to yield a high-purity, stable powder form suitable for various applications.
| Synonyms | hyaluronic acid sodium salt, sodium hyaluronate, hyaluronan sodium, and HA sodium salt. |
| CAS no. | 9067-32-7 |
| EINECS no. | 618-620-0 |
| Molecular formula | (C14H20NNaO11)n |
| Molecular weight | 403.32 |
| Structure |  |
APPLICATIONS
| Ophthalmic solutions |
| It is used as an aid in ophthalmic surgery. |
| Osteoarthritis injections. |
| Cosmetics (as a hydrating and anti-aging ingredient. |
| Medical devices (including dermal fillers and wound healing formulations) |
| Advanced Delivery Systems :Encapsulated sodium hyaluronate provides controlled release mechanisms. |
| Pharmaceuticals : In topical preparations it functions like a nanocarrier. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White or almost white, powder or fibrous aggregate |
| Identification | ||
| Appearance of solution | – – | Should be Clear A 600nm ≤ 0.01 |
| Reaction (a) of Sodium | – | Should give positive reaction |
| pH | – | 5.0-8.5 |
| Loss on drying | % | NMT 20 |
| Intrinsic Viscosity | m3/kg | 1.2 – 2.8 |
| Nucleic acids | A260 nm | < 0.5 |
| Protein | % | NMT 0.1% |
| Chlorides | % | NMT 0.5 |
| Iron | ppm | NMT 30 |
| Microbial contamination (TAMC) | cfu /g | NMT 100 |
| Bacterial endotoxins | IU/mg | NMT 0.5 |
| Assay (On dried basis) | % | 95.0 – 105.0 |
| Residual Solvents (Additional In-house Test) | ||
| Ethanol | ppm | NMT 5000 |
PACKING
100 g bottles for smaller quantities, 25 kg drums and 200 kg drums for commercial quantities.
STORAGE
Store in airtight container, protected from light and humidity between 2-8°C
REACH status
Not registered
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