INTRODUCTION
Pyrazinamide is a first-line antitubercular drug used in combination therapy for the treatment of tuberculosis (TB). It is a synthetic pyrazine derivative and acts as a prodrug, which is converted into its active form (pyrazinoic acid) inside Mycobacterium tuberculosis.
It is particularly effective in the initial intensive phase of TB therapy, where it helps shorten the total duration of treatment recommended by the World Health Organization.
MANUFACTURE
Pyrazinamide is typically produced from pyrazine intermediates through carboxamide formation.
| Synonym(s) | Pyrazine-2-carboxamide |
| CAS no. | 98-96-4 |
| EINECS no. | 202-717-6 |
| Molecular formula | C5H5N3O |
| Molecular weight | 123.11 |
| Structure |  |
APPLICATIONS
| Pharmaceutical |
| First-line antituberculosis medication |
| Used in combination with drugs such as: |
| Isoniazid |
| Rifampicin |
| Ethambutol |
| Therapeutic role |
| Active against semi-dormant tubercle bacilli |
| Helps reduce TB treatment duration from ~9–12 months to ~6 months |
| Improves sterilizing activity in acidic environments (e.g., macrophages) |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | A white or almost white crystalline powder |
| Solubility | – | Sparingly soluble in wáter, slightly soluble in ethanol (96%) and in methylene chloride |
| Identification C | – | Test C – IR spectrum of should be concordant to that of similar recorded spectrum of WRS of Pyrazinamide |
| Appearance of solution | – | Solution S is clear and colourless |
| Acidity or Alkalinity | – | Complies as per EP |
| Related substances 1.Impurity A 2.Impurity B 3.Unspecified impurities 4.Total impurity | % % % % | NMT 0.05% NMT 0.05% NMT 0.05% NMT 0.2% |
| Water (by KF) | % | Max 0.5 |
| Sulfated ash | % | Max 0.1 |
| Assay (by Potentiometrically) | % | Between 99.0 to 101.0 |
PACKING
25 kg HDPE drum
STORAGE
Store in cool place protected from Light and Moisture
CERTIFICATIONS
WHO-GMP, WC, CEP
ExSyn offers Pyrazinamide on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need additional information or SDS, please contact us.
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