INTRODUCTION
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
MANUFACTURE
Industrial production of 5-Nitro Isophthalic Acid is generally carried out either through the nitration of isophthalic acid using concentrated nitric acid and concentrated sulfuric acid under controlled reaction conditions, or by the oxidation of 1,3-dimethyl-5-nitrobenzene using potassium permanganate (KMnO₄) under carefully controlled conditions.
| Synonyms | 5-Nitro-1,3-benzenedicarboxylic acid; 1-Nitrobenzene-3,5-dicarboxylic acid; 5-Nitro-m-phthalic acid. |
| CAS no. | 618-88-2 |
| EINECS no. | 210-568-3 |
| Molecular formula | C8H5NO6 |
| Molecular weight | 211.13 |
| Structure |  |
APPLICATIONS
5-Nitro Isophthalic Acid is valued because of its chemically versatile nature, both nitro and carboxyl groups allow multiple downstream reactions. It serves as a strategic intermediate in specialty chemical manufacturing.
| Pharmaceutical Intermediates: |
| • 5-NIPA is widely used as a key intermediate in the manufacture of contrast media such as Iohexol, a non-ionic, contrast agent commonly employed in medical imaging procedures as CT scans, angiography, and urography to enhance the visibility of internal body structures. |
| • Used in synthesis of antibacterial compounds, anti-inflammatory molecules, etc. |
| Dye and Pigment Industry: |
| Acts as an intermediate for |
| • Azo dyes, specialty pigments and color-forming aromatic compounds. |
| Polymer and Resin Chemistry: |
| The dicarboxylic acid groups participate in polymerization reactions |
| • Used in specialty polyesters, functional polymers and high-performance resins. |
| Metal–Organic Frameworks (MOFs): |
| Metal–Organic Framework research frequently uses nitro-substituted aromatic dicarboxylic acids as ligands. |
| Applications include: |
| • Gas storage, catalysis, sensors and separation technology. |
| Additionally, 5-NIPA is used in co-ordination chemistry and preparation of advanced materials. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to yellow-solid powder |
| Melting range | °C | Between 258.0 to 264.0 |
| Loss on drying | % w/w | NMT 0.5 |
| Assay by titration | % w/w | Between 98.0 to 102.0 |
| Purity (by HPLC): | ||
| 5-Nitro isophthalic acid | % | NLT 99.0 |
| Any single Impurity | % | NMT 0.5 |
| Total impurities | % | NMT 1.0 |
STORAGE & PRECAUTION
Keep container tightly closed at ambient temperature.
PACKING
UN Approved drums;
Packaging quantities (net weight/volume per container): 30 kg/drum, 250 kg/drum
Primary Packaging (material of construction of packaging and closure): Plastic drums
REACH Status
Not registered
ExSyn offers 5-Nitro isophthalic acid (5-NIPA) on a commercial scale and welcomes your enquiries. Regardless of the quantity required, our commitment to exceptional quality and reliable service makes ExSyn the preferred supplier of choice. Should you require any additional information or the SDS, please feel free to contact us.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.
Zinc Dialkyl Dithio Phosphate (ZDDP) belongs to a family of coordination compounds classified as members of transition metal dithiophosphate.
ZDDP is widely used based on a combination of different selected alcohols thus providing antiwear performance and enhanced thermal and hydrolytic stability. In combination with other additives, it is especially used for the formulation of hydraulic fluids, industrial gear oils, metalworking fluids, greases and automotive engine oils.
Dibutyl sulfide is an organosulfur. It is a clear, colorless to pale yellow liquid characterized by a strong sulfur-like odor and is primarily used as an intermediate in chemical synthesis, specialty organic manufacturing, and research applications. The compound exhibits good solvency properties and moderate thermal stability, making it useful in industrial and laboratory processes involving sulfur-containing organic compounds.
Oleylamine is a long-chain (C18) primary fatty amine derived from natural fatty acids, typically sourced from vegetable oils. It is produced from oleic acid through conversion of the carboxylic acid group (–COOH) into an amine group (–NH₂). With its optimal balance of hydrophobic chain length and reactive amine functionality it serves as a versatile and dependable building block for high-performance formulations.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
Pyrazinamide is a first-line antitubercular drug used in combination therapy for the treatment of tuberculosis (TB). It is a synthetic pyrazine derivative and acts as a prodrug, which is converted into its active form (pyrazinoic acid) inside Mycobacterium tuberculosis.
6-Bromopyridine-2,3-diamine is a heterocyclic organic compound belonging to the class of substituted pyridines. It is used mainly as an intermediate in pharmaceuticals and agrochemicals.
Magnesium trisilicate is an inorganic compound commonly used in pharmaceutical and gastrointestinal (GI) preparations due to its dual action. It is usually produced as a white, odorless, fine powder. It helps bind toxins or irritants in the gastrointestinal tract and occasionally used in formulations for its stabilizing properties.
Choline salicylate is a salicylate salt formed from choline and salicylic acid. It is a non-steroidal anti-inflammatory agent (NSAID-type compound) mainly used for its analgesic, anti-inflammatory, and mild antiseptic properties. Unlike acetylated salicylates, it is less irritating to the gastric mucosa and is commonly used in topical oral preparations such as gels and mouth paints.