INTRODUCTION
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
MANUFACTURE
Industrial production of 5-Nitro Isophthalic Acid is generally carried out either through the nitration of isophthalic acid using concentrated nitric acid and concentrated sulfuric acid under controlled reaction conditions, or by the oxidation of 1,3-dimethyl-5-nitrobenzene using potassium permanganate (KMnO₄) under carefully controlled conditions.
| Synonyms | 5-Nitro-1,3-benzenedicarboxylic acid; 1-Nitrobenzene-3,5-dicarboxylic acid; 5-Nitro-m-phthalic acid. |
| CAS no. | 618-88-2 |
| EINECS no. | 210-568-3 |
| Molecular formula | C8H5NO6 |
| Molecular weight | 211.13 |
| Structure |  |
APPLICATIONS
5-Nitro Isophthalic Acid is valued because of its chemically versatile nature, both nitro and carboxyl groups allow multiple downstream reactions. It serves as a strategic intermediate in specialty chemical manufacturing.
| Pharmaceutical Intermediates: |
| • 5-NIPA is widely used as a key intermediate in the manufacture of contrast media such as Iohexol, a non-ionic, contrast agent commonly employed in medical imaging procedures as CT scans, angiography, and urography to enhance the visibility of internal body structures. |
| • Used in synthesis of antibacterial compounds, anti-inflammatory molecules, etc. |
| Dye and Pigment Industry: |
| Acts as an intermediate for |
| • Azo dyes, specialty pigments and color-forming aromatic compounds. |
| Polymer and Resin Chemistry: |
| The dicarboxylic acid groups participate in polymerization reactions |
| • Used in specialty polyesters, functional polymers and high-performance resins. |
| Metal–Organic Frameworks (MOFs): |
| Metal–Organic Framework research frequently uses nitro-substituted aromatic dicarboxylic acids as ligands. |
| Applications include: |
| • Gas storage, catalysis, sensors and separation technology. |
| Additionally, 5-NIPA is used in co-ordination chemistry and preparation of advanced materials. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to yellow-solid powder |
| Melting range | °C | Between 258.0 to 264.0 |
| Loss on drying | % w/w | NMT 0.5 |
| Assay by titration | % w/w | Between 98.0 to 102.0 |
| Purity (by HPLC): | ||
| 5-Nitro isophthalic acid | % | NLT 99.0 |
| Any single Impurity | % | NMT 0.5 |
| Total impurities | % | NMT 1.0 |
STORAGE & PRECAUTION
Keep container tightly closed at ambient temperature.
PACKING
UN Approved drums;
Packaging quantities (net weight/volume per container): 30 kg/drum, 250 kg/drum
Primary Packaging (material of construction of packaging and closure): Plastic drums
REACH Status
Not registered
ExSyn offers 5-Nitro isophthalic acid (5-NIPA) on a commercial scale and welcomes your enquiries. Regardless of the quantity required, our commitment to exceptional quality and reliable service makes ExSyn the preferred supplier of choice. Should you require any additional information or the SDS, please feel free to contact us.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.