INTRODUCTION
Triphenylphosphine is a common organophosphorus compound that is frequently abbreviated as PPh3 or Ph3P. It is widely used in organic and organometallic compound synthesis because it is an effective reducing agent as well as a neutral ligand. At room temperature, PPh3 crystals are relatively air-stable and colourless.
MANUFACTURE
The industrial synthesis involves the reaction between phosphorus trichloride, chlorobenzene, and sodium.
| Synonym | Triphenylphosphane,Phosphorus triphenyl |
| CAS no. | 603-35-0 |
| EINECS no. | 210-036-0 |
| Molecular formula | C18H15P |
| Molecular weight | 262.29 g/mol |
| Structure |  |
| APPLICATIONS |
|---|
| Triphenylphosphine is used in the synthesis of Chlorambucil, which has been shown to be cytotoxic in breast and pancreatic cancers. |
| It is also used to make -Tocopherol analogues for monitoring antioxidant status. |
| Used in the synthesis of Vitamin D2, Vitamin A, Clindamycin, and other drugs. |
| Also, used in a variety of applications, including sensitizers, heat stabilizers, light stabilizers, antioxidants, flame retardants, antistatic agents, rubber antiozonants, and analytical reagents. |
| The Wittig reaction, which converts aldehydes and ketones to alkenes, was Ph3P’s first significant use in organic synthesis. |
| Triphenylphosphine is also used as a transition metal-ligand in olefin polymerizations and in the Suzuki, Mitsunobu, and Appel reactions. |
| In homogeneous catalysis, triphenylphosphine is a standard ligand. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Description | – | A white to off white crystalline powder or flakes |
| Solubility | – | Soluble in toluene |
| Melting range | °C | 78.0 to 83.0 |
| Loss on drying | % w/w | Not more than 0.5 |
| Assay (by chemical) | % | Not less than 99.0 |
PACKING
25 kg HDPE bag.
STORAGE
Store in a dry and well-ventilated place.
REACH
Not registered.
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