INTRODUCTION
2,6-Lutidine is a liquid product and a semi-volatile compound naturally abundant in tobacco. Its main applications is as reagent in pharmaceuticals and as a solvent in chemical processes.
Manufacture
It is produced by fractionation of crude pyridine base, which is in turn is obtained from coal tar. The co-products are alpha-picoline, gamma-picoline, and 3,4-lutidine. Another industrial process uses formaldehyde, acetone, and ammonia.
| Synonyms | 2,6-Dimethylpyridine alpha,alpha’-dimethylpyridine |
| CAS no. | 108-48-5 |
| EINECS no. | 203-587-3 |
| Molecular formula | C7H9N |
| Molecular weight | 107.15 |
| Structure |  |
Applications in APIs
| The dialkylated pyridine is a KRM for production of APIs: |
|---|
| Clopidol – a veterinary medicine, used as coccidiostat. |
| Cefpiramide acid – an antibiotic |
Applications in Intermediates
| Amongst many others, the following intermediates are synthesized from 2,6-lutidine: |
|---|
| 2,6-Dimethylpiperidine |
| Dipicolinic acid |
| 2,6-Dimethylpyridine-4-amine |
| 2-Bromomethyl-6-methylpyridine |
| 2,6-Dimethylpyridine-N-oxide |
Other Applications
| As a sterically hindered mild base in organic syntheses |
| Used as food additive to impart nutty odor and flavor |
| Acts as an accelerator in vulcanization processes employed in dyes, rubber, and resin industries |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Monophase clear colorless liquid with no foreign impurities |
| Solubility | – | Soluble in methanol and cold water |
| Boiling point | °C | 144-145 |
| Color | APHA | Max 20 |
| Moisture by KF | % | Max 0.2 |
| Identification by IR | – | IR spectrum of the sample to be concordant with standard spectrum |
| Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
190 kg UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2,6-lutidine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.
Zinc Dialkyl Dithio Phosphate (ZDDP) belongs to a family of coordination compounds classified as members of transition metal dithiophosphate.
ZDDP is widely used based on a combination of different selected alcohols thus providing antiwear performance and enhanced thermal and hydrolytic stability. In combination with other additives, it is especially used for the formulation of hydraulic fluids, industrial gear oils, metalworking fluids, greases and automotive engine oils.
Dibutyl sulfide is an organosulfur. It is a clear, colorless to pale yellow liquid characterized by a strong sulfur-like odor and is primarily used as an intermediate in chemical synthesis, specialty organic manufacturing, and research applications. The compound exhibits good solvency properties and moderate thermal stability, making it useful in industrial and laboratory processes involving sulfur-containing organic compounds.
Oleylamine is a long-chain (C18) primary fatty amine derived from natural fatty acids, typically sourced from vegetable oils. It is produced from oleic acid through conversion of the carboxylic acid group (–COOH) into an amine group (–NH₂). With its optimal balance of hydrophobic chain length and reactive amine functionality it serves as a versatile and dependable building block for high-performance formulations.