INTRODUCTION
The bi-naphthol moiety is a colorless solid. The structure depicts two naphthol rings joined at the respective 1-positions. The presence of two hydroxy groups renders the molecule highly reactive and the product forms a backbone of a variety of value-added chemicals and ligands.
| Synonyms | 1,1’-bi-2-naphthol |
| CAS no. | 602-09-5 |
| EINECS no. | 210-014-0 |
| Molecular formula | C2OH14O2 |
| Structure | (download pdf to view) |
| Molecular weight | 286.32 |
APPLICATIONS
The bi-naphthyl structure serves as an important ligand for asymmetric synthesis in organic chemistry, especially in Diels-Alder reactions, carbonyl addition and reductions.
Some key applications are:
| 2,2’-bis(diphenylphosphino)-1,1’-binaphthyl (BINAP) |
| (S)-Binol by resolution of the mother binol |
| (R)-Binol in the same resolution process |
| Aluminium Lithium bi(binaphthol) (its (R)-enantiomer) |
| (S)-Vanol |
A very recent but path-breaking application of Binol has been in preparation of one of the Covid-19 vaccines being developed and supplied from India.
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | White to off-white powder |
| Identification By IR | – | Conforms to reference spectrum |
| Identification By Proton NMR | – | Conforms to reference spectrum |
| Purity By HPLC | % | NLT 99.0 |
| Moisture | Wt. % | NMT 0.5 |
STORAGE
The product is stored at ambient temperature.
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