Tetrabutylammonium fluoride trihydrate (TBAF trihydrate) is a hygroscopic solid and is a versatile reagent in many chemical reactions. It us usually consumed in aldol-type condensation, Michael-type, and ring opening reactions.
TBAF trihydrate is produced by reaction of aqueous hydrogen fluoride with aqueous solution of tetrabutylammonium bromide over an Amberlite resin.
|Synonyms||Tetrabutylazanium fluoride trihydrate|
|Molecular formula||C16H36NF. 3H2O|
|The quaternary ammonium salt has many applications such as:|
|phase transfer catalyst|
|mild base in organic reactions|
|source of fluoride anion in organic solvents|
|reactant in synthesis of cellulose derivatives, lipophilic peptides, and in dehydrobromination reactions|
|deprotecting agent to remove silyl ether protecting group|
|It also plays an important in conversion of O-silylated enolates into carbonyl compounds in presence of DMSO.|
|Appearance||–||White to slight yellow solid small lumps|
|Water by KF||%||14.00 – 19.00|
|Assay by titration||%||Min 98.0|
Stored at ambient temperature.
25 kg HDPE drum.
Not registered yet.
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