INTRODUCTION
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It is an organic heterotetracyclic compound that has a Furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
Manufacture
The two step manufacturing process involves extraction of crude Podophyllotoxin from harvested root of Podophyllum E.modi using suitable solvent followed by crystallization and oven drying.
| Synonym | 1,3,3a,4,9,9a-Hexahydro-9-hydroxy-6,7-(methylenedioxy)-4-(3′,4′,5′- trimethoxyphenyl)benz[f]isobenzofuran-3-one |
| Plant Source | Podophyllum E. Modi |
| Part of Plant | Root |
| CAS no. | 518-28-5 |
| EINECS no. | 208-250-4 |
| Molecular formula | C22H22O8 |
| Molecular weight | 414.41 |
| Structure |  |
Applications
| APIs |
|---|
| Podophyllotoxin is classified as ATC class: D06BB04 drug and is listed in WHO’s list of Essential Medicines |
| Antineoplastic and antiviral activities are the most pronounced pharmacological effects of Podophyllotoxin. It is a cytotoxic agent that binds to DNA and inhibits protein synthesis |
| Podophyllotoxin has also been shown to have anti-cancer effects in leukemia and other cancers, as well as being a potential anticancer drug for acute leukemia. It has been shown to induce oxidative stress and cell death in cancer cells |
| It is used for the topical treatment of genital warts in children and dermatological conditions caused by Psoriasis vulgaris as well as Molluscum contagisum infections |
| It may also be used as a therapeutic agent to treat genital tumors, Wilms tumors, lung cancer, and lymphomas |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | Visual | White to off-white powder; no visible evidence of contamination |
| Identification by IR | – | To conform to structure |
| Melting point | °C | 175.0 – 185.0 |
| Assay by HPLC | % | Min 90.0 |
| Heavy Metals | ppm | Max 20.0 |
| % Volatiles by LOD (2 hours, 105°C under vacuum ) | % | Max 3.0 |
| Chromatographic Purity by HPLC | ||
| 4’-Demethylpodophyllotoxin | % | Max 8.0 |
| Specified impurity @ RRT 0.80 | % | Max 0.5 |
| Specified impurity @ RRT 1.34 | % | Max 1.0 |
| Specified impurity @ RRT 2.4 | % | Max 0.5 |
| Picropodophyllin | % | Max 0.5 |
| Individual unknown impurities | % | Max 0.5 |
STORAGE
Stored at 2 °C – 8°C
PACKING
15 kg UN approved cartons
REACH Status
Not registered
ExSyn offers Podophyllotoxin Crude on commercial scales under refrigerated transport and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
INTRODUCTION Guanosine 5’-diphosphate disodium salt (GDP·Na2) is a purine nucleoside diphosphate that plays a crucial role in various biochemical processes. It is a nucleoside consisting of the base guanine and the sugar riboseIt has two phosphate groups, which affects its function and interactions with enzymes. It is a salt form where two sodium ions are […]
INTRODUCTION Rheological additives are essential components in paint formulations used to control the flow and viscosity of the paint. Modified rheological additives are advanced formulations of traditional rheological additives. They are designed to offer improved performance, versatility, or specific functional properties in applications like paints, coatings etc. Synonym Alkyl quaternary ammonium bentonite CAS no. 68153-34-4 […]
Curcumin, a compound found in turmeric, is known for its anti-inflammatory and antioxidant properties. Introducing 95% curcumin in both human and animal applications involves understanding its high potency, ensuring effective delivery and absorption
Titanium Dioxide (TiO₂) is one of the most important and widely used white pigments in the world. It’s a versatile compound found in an array of products across various industries. Its exceptional properties make it an essential ingredient in everything from paints and coatings to adhesives and cosmetics. TiO₂ exists in two primary grades: Anatase and Rutile.
Hydriodic acid is a strong acid solution of hydrogen iodide in water at nominal concentrations of 47% and 57%. Its stabilized formulation ensures consistent quality and reliability in various applications. This compound often appears as a colorless to pale yellow liquid with a sharp, pungent odor, characteristic of hydrogen halides.
n-Propylamine, known as propylamine in trade, is a versatile primary amine with a lone pair of electrons on nitrogen atom. It makes the amino group reactive and the amine thus undergoes chiefly nucleophilic substitution reactions with substrate.
Iodine is anon-metallic, dark-grey/purple-black, lustrous, solid element. It is the heaviest and the rarest of stable halogens that can be found on the crust of earth.About fifty percent of all iodine produced and manufactured worldwide is used to form Organoiodine compounds. Iodine is an important element for many health-sustaining processes and essential for human thyroid health.
The product, acronymed Oct-NBE, is an organic compound with a cyclic ring system and a 8-membered hydrophobic chain. The structure renders the chemical special properties leading to its applications in diverse fields.
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.