INTRODUCTION

Pyrophosphoryl chloride is colourless to pale yellow liquid, reasonably easy to handle. It reacts violently with water & miscible with most organic solvents.
It is used in pharmaceutical and other organic synthesis, as laser materials and electronic components.

Manufacture
Pyrophosphoryl chloride is prepared by reacting dichlorophosphoric acid, or a mixture containing the acid with phosphorus pentachloride in the absence of water.

SynonymsPyrophosphoric tetrachloride
Pyrophosphoryl chloride
Diphosphoric tetrachloride
CAS no.13498-14-1
EINECS no.236-824-4
Molecular formulaP2O3Cl4
Molecular weight251.76
Structure

Applications

Pyrophosphoryl chloride serves as a reductive chlorination reagent used in the synthesis of quetiapine.
It acts as a phosphorylating agent involved in nucleoside synthesis.
It plays an important role in Vilsmeier formylation and glyoxylation reactions.
Diphosphoryl chloride is used in the synthesis of potent and orally bioavailable tricyclic CGRP receptor antagonists.
Also used in the synthesis of transition state analogue inhbitors of inosine monophosphate.

SPECIFICATIONS

TestUnitSpecification
CharacteristicsColorless, smoking, corrosive liquid
Specific gravity1.80 – 1.82
Assay by Chloride%Min 99.0
Assay by Acidimetric%Min 99.0

STORAGE
Moisture Sensitive. Air Sensitive. Store under Nitrogen. Ambient temperatures.

PACKING
40 kg UN approved carboys.

REACH Status
Not registered yet.

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