INTRODUCTION
Pivaloyl chloride is a colorless to light yellow liquid with a pungent mustard-like odor. It hydrolyses in the presence of water. It is a reactive intermediate used in the production of agricultural chemicals and pharmaceuticals and in peroxyesters manufacturing.
Manufacturing
It is made by reacting pivalic acid with phosphorus pentachloride.
| Synonyms | PVCL Trimethylacetyl chloride 2,2-dimethyl propanoyl chloride Pivalic acid chloride |
| CAS no. | 3282-30-2 |
| EINECS no. | 221-921-6 |
| Molecular formula | C5H9ClO |
| Molecular weight | 120.58 |
| Structure |  |
Applications
| Pivaloyl chloride is used in the production of pharmaceuticals, agrochemicals and other organic compounds. Some of them listed below: |
|---|
| It is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. |
| It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. |
| It is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. |
| It is used for pesticide intermediates production, such as Chloropivaloyl chloride. |
| It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear liquid |
| Color (APHA/HAZEN) | – | Max 20.0 |
| Identification by GC | – | Should comply |
| Specific gravity @ 20°C | g/cm3 | 0.975 – 0.985 |
| Free Sulphur dioxide | % | Max 0.2 |
| Free Hydrochloric acid | % | Max 0.2 |
| Pivalic acid | % | Max 0.2 |
| Pivalic anhydride | % | Max 0.2 |
| Purity (by GC) | % Area | Min 99.0 |
STORAGE
Stored in a dry area and at ambient temperature.
PACKING
200 kg UN approved drum.
REACH status
Pivaloyl chloride offered by ExSyn is EU REACH registered.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Methyl magnesium chloride is the simplest of Grignard’s reagents. The neat molecule is sensitive to air and moisture. Therefore, it is offered as solution in THF with variable molarity values.
Polysorbate 20 is a gentle, oily, liquid cosmetic additive that functions as a non-ionic surfactant and wetting agent that enhances the spread-ability of liquids.
Iodomethane, also known as methyl iodide, is a colorless, non-flammable liquid with pungent, ethereal odor that darkens on exposure to light. It occurs naturally in oceans as a product of marine algae.
1,4-Dibromobutane is a chemical compound from the group of aliphatic, saturated halogenated hydrocarbons. 1,4-Dibromobutane shows similar reactions as the mono-brominated 1-bromobutane, however, in contrast, it is doubly functionalized.
Tetrabutylammonium fluoride trihydrate (TBAF trihydrate) is a hygroscopic solid and is a versatile reagent in many chemical reactions. It us usually consumed in aldol-type condensation, Michael-type, and ring opening reactions.
Pyrophosphoryl chloride is colourless to pale yellow liquid, reasonably easy to handle. It reacts violently with water & miscible with most organic solvents.
It is used in pharmaceutical and other organic synthesis, as laser materials and electronic components.
Benzilic acid ethyl ester is an oil organic liquid. Its reactivity is attributed to the presence of the hydroxyl group at alpha-position to the carboxylic acid group and hence it participates in various reactions leading to value-added intermediates and APIs.
Bromobenzene, an aryl halide, is a clear, colorless liquid with a pleasant odor. It is soluble in methanol and diethyl ether, and very slightly soluble in cold water.
Dibutyltin laurate is an organotin compound with oily appearance. The lauric acid ester is used in various industrial applications as catalyst.