INTRODUCTION
Pivaloyl chloride is a colorless to light yellow liquid with a pungent mustard-like odor. It hydrolyses in the presence of water. It is a reactive intermediate used in the production of agricultural chemicals and pharmaceuticals and in peroxyesters manufacturing.
Manufacturing
It is made by reacting pivalic acid with phosphorus pentachloride.
| Synonyms | PVCL Trimethylacetyl chloride 2,2-dimethyl propanoyl chloride Pivalic acid chloride |
| CAS no. | 3282-30-2 |
| EINECS no. | 221-921-6 |
| Molecular formula | C5H9ClO |
| Molecular weight | 120.58 |
| Structure |  |
Applications
| Pivaloyl chloride is used in the production of pharmaceuticals, agrochemicals and other organic compounds. Some of them listed below: |
|---|
| It is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. |
| It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. |
| It is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. |
| It is used for pesticide intermediates production, such as Chloropivaloyl chloride. |
| It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear liquid |
| Color (APHA/HAZEN) | – | Max 20.0 |
| Identification by GC | – | Should comply |
| Specific gravity @ 20°C | g/cm3 | 0.975 – 0.985 |
| Free Sulphur dioxide | % | Max 0.2 |
| Free Hydrochloric acid | % | Max 0.2 |
| Pivalic acid | % | Max 0.2 |
| Pivalic anhydride | % | Max 0.2 |
| Purity (by GC) | % Area | Min 99.0 |
STORAGE
Stored in a dry area and at ambient temperature.
PACKING
200 kg UN approved drum.
REACH status
Pivaloyl chloride offered by ExSyn is EU REACH registered.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.
Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Bakuchiol is known as Vegan Retinol as it has ability to improve uneven skin tone by reducing the appearance of dark spots and pigmentation. It is best in class of anti-aging and anti-wrinkles effect.