N-Acetyl-L-aspartic acid, abbreviated as NAA, is second most abundant molecule in nervous systems after amino acid glutamate. It is synthesized in brain from aspartic acid and acetyl co-enzyme A. It also acts as nutrient.
In a biological process, NAA is produced from rat brain acetone. Commercially, it is manufactured by acetylation of L-aspartic acid bis(trimethylsilyl)ester using acetyl chloride.
Applications in Synthesis
|The chiral acid is used to synthesize:|
|As reagent in selective reductions of cyclic ketones|
|In acid-catalyzed cyclization reactions|
|In peptide synthesis|
|As a nutraceutical supplement in capsule, tablet, and liquid dosage form|
|As human and rat metabolites|
|Isotopic form used in studies for metabolic alteration associated with schizophrenia|
|Specific rotation (C = 1, HAc)||Degree||50.0 – 54.0|
The product is stored at ambient temperature.
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