INTRODUCTION
N-Acetyl-L-aspartic acid, abbreviated as NAA, is second most abundant molecule in nervous systems after amino acid glutamate. It is synthesized in brain from aspartic acid and acetyl co-enzyme A. It also acts as nutrient.
Manufacture
In a biological process, NAA is produced from rat brain acetone. Commercially, it is manufactured by acetylation of L-aspartic acid bis(trimethylsilyl)ester using acetyl chloride.
Synonyms | N-Acetyl aspartate NAA |
CAS no. | 997-55-7 |
EINECS no. | 213-643-9 |
Molecular formula | C6H9NO5 |
Molecular weight | 175.14 |
Structure | ![]() |
Applications in Synthesis
The chiral acid is used to synthesize: |
---|
Its anhydride |
Homoserine gamma-lactones |
Other Applications
As reagent in selective reductions of cyclic ketones |
In acid-catalyzed cyclization reactions |
In peptide synthesis |
As a nutraceutical supplement in capsule, tablet, and liquid dosage form |
As antioxidant |
As human and rat metabolites |
Isotopic form used in studies for metabolic alteration associated with schizophrenia |
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | White powder |
Specific rotation (C = 1, HAc) | Degree | 50.0 – 54.0 |
Water | % | Max 0.5 |
Assay | % | Min 98.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
25 kg Fibre drum.
REACH Status
Not Registered yet.
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