INTRODUCTION
Caffeine (anhydrous) is a naturally occurring methylxanthine derivative used as a CNS stimulant, to restore mental alertness and wakefulness in patients experiencing fatigue or drowsiness.
Manufacturing
Caffeine anhydrous is made from the seeds and leaves of green coffee plants. The word “anhydrous” means “without water.” After harvesting, caffeine is extracted from the plant matter and dehydrated. This produces a highly concentrated caffeine powder.
| Synonyms | Methyltheobromine 1,3,7-Trimethylxanthine |
| CAS no. | 58-08-2 |
| EINECS no. | 200-362-1 |
| Molecular formula | C8H10N4O2 |
| Molecular weight | 194.19 |
| Structure |  |
Applications
| Caffeine anhydrous is used as stimulant drug in |
|---|
| Food production |
| Beverage such as in coffee, tea, soda drink to stimulate the central nervous |
| Pharmaceutical |
| In Health and Personal care |
|---|
| Caffeine anhydrous is used as Fragrance Ingredient; Skin-Conditioning agent. |
| Primary short-term effects of Caffeine are: |
|---|
| Increasing resting heart rate |
| Psychostimulation |
| Constricting blood vessels |
| Dilating the bronchioles |
| Slightly increasing metabolic rate |
| Increasing urine production and gastric motility |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Description | – | A white crystalline powder; sublimes readily |
| Solubility | – | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol and in ether. It dissolves in concentrated solutions of alkali benzoates or salicylates. |
| Identification A | – | By IR absorption identical with Std. |
| Identification B | – | To Comply |
| Water | % | NMT 0.5 |
| Melting Range | °C | Between 235.0 – 237.5 after drying at 80°C for 4 hours |
| Residue on Ignition | % | NMT 0.1 |
| Arsenic | ppm | NMT 3.0 |
| Heavy Metals | % | NMT 0.001 |
| Readily Carbonizable Substances | – | The solution has no more color than matching Fluid D. |
| Residual solvents | – | To Comply |
| Other Alkaloids | – | No precipitate is formed |
| Chromatographic Purity – Any individual impurity | % | NMT 0.1 |
| Total impurity | % | NMT 0.1 |
| Assay | % | NLT 98.5 & NMT 101.0 on anhydrous basis |
STORAGE
Store in a cool, dry, well-ventilated area.
PACKING
25 kg drum.
REGISTRATION / CERTIFICATION
ISO, FSSAI, HALAL, KOSHER, GMP & US-DMF.
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