INTRODUCTION

Caffeine (anhydrous) is a naturally occurring methylxanthine derivative used as a CNS stimulant, to restore mental alertness and wakefulness in patients experiencing fatigue or drowsiness.

Manufacturing
Caffeine anhydrous is made from the seeds and leaves of green coffee plants. The word “anhydrous” means “without water.” After harvesting, caffeine is extracted from the plant matter and dehydrated. This produces a highly concentrated caffeine powder.

SynonymsMethyltheobromine
1,3,7-Trimethylxanthine
CAS no.58-08-2
EINECS no.200-362-1
Molecular formulaC8H10N4O2
Molecular weight194.19
Structure

Applications

Caffeine anhydrous is used as stimulant drug in
Food production
Beverage such as in coffee, tea, soda drink to stimulate the central nervous
Pharmaceutical
In Health and Personal care
Caffeine anhydrous is used as Fragrance Ingredient; Skin-Conditioning agent.
Primary short-term effects of Caffeine are:
Increasing resting heart rate
Psychostimulation
Constricting blood vessels
Dilating the bronchioles
Slightly increasing metabolic rate
Increasing urine production and gastric motility

SPECIFICATIONS

TestUnitSpecification
DescriptionA white crystalline powder; sublimes readily
SolubilitySparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol and in ether. It dissolves in concentrated solutions of alkali benzoates or salicylates.
Identification ABy IR absorption identical with Std.
Identification BTo Comply
Water%NMT 0.5
Melting Range°CBetween 235.0 – 237.5 after drying at 80°C for 4 hours
Residue on Ignition%NMT 0.1
ArsenicppmNMT 3.0
Heavy Metals%NMT 0.001
Readily Carbonizable SubstancesThe solution has no more color than matching Fluid D.
Residual solventsTo Comply
Other AlkaloidsNo precipitate is formed
Chromatographic Purity
– Any individual impurity
%NMT 0.1
Total impurity%NMT 0.1
Assay%NLT 98.5 & NMT 101.0 on anhydrous basis

STORAGE
Store in a cool, dry, well-ventilated area.

PACKING
25 kg drum.

REGISTRATION / CERTIFICATION
ISO, FSSAI, HALAL, KOSHER, GMP & US-DMF.

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