4-Methoxypyridine, a molecule with ether function, is a reactive base. Its nitrogen atom is activated by the methoxy group. It renders the molecule active and thus 4-methoxypyrimidine participates in many chemical processes. Its uses are in intermediates, in synthesis of biologically active moieties, and in proteomic research.

The compound is produced by ether formation reaction between methanol and 4-bromopyridine.  Alternative synthesis route is catalytic hydrogenation of 4-methoxypyridine-N-oxide.

Methyl pyridin-4-yl ether
CAS no.620-08-6
EINECS no.210-624-7
Molecular formulaC6H7NO
Molecular weight109.13

Applications in Proteins
In proteomic research, 4-methoxypyridine is used in synthesis of benzoylated N-ylides, which in turn act as protein farnesyltransferase inhibitor.

Applications in Intermediates
Amongst few others, the following intermediates are manufactured from 4-methoxypyridine:


Other Applications

As building block for synthesis of some biologically active compounds
Its o-lithiated derivative used as metalating base in synthetic chemistry
As a starting reagent for stereo-controlled synthesis of (±)-pumiliotoxin C and (±)-lasubine II
In efficient construction of dihyropyridin-4-ones, which in turn serve as potential ligands for neuronal nicotinic acetycholine receptors
As flavoring agent in food


AppearanceClear colorless to pale yellow liquid
Moisture by KF%Max 0.5
Purity by GC%Min 97

The product is stored at ambient temperature.

180 kg Composite drum.

REACH Status
Not registered yet.

ExSyn offers 4-Methoxypyridine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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