INTRODUCTION
4-Amino-1,2,4-triazole is an organic solid belonging to the heterocyclic category of compounds. By virtue of presence of 3 nitrogen atoms, the molecule is biologically active and thus acts as antimicrobial and antifungal agent.
Manufacture
It is manufactured by Schmidt reaction in which hydrazine reacts with an aromatic nitrile in aqueous solution to form 4-amino-1,2,4-triazole.
| Synonym | 4H-1,2,4-triazol-4-amine 4-Amino-4H-1,2,4-triazole |
| CAS no. | 584-13-4 |
| EINECS no. | 209-533-5 |
| Molecular formula | C2H4N4 |
| Molecular weight | 84.08 |
| Structure |  |
Applications
| APIs |
|---|
| Carvedilol, an antihypertensive drug |
| Ondansetron, serotonin 5-HT3 receptor antagonist |
| Intermediates |
|---|
| 1-(4-Nitrophenyl)methyl-1,2,4-triazole |
| 4-Amino-1,2,4-triazole HCl |
| 6,8-Dimethyl[1,2,4]triazolo[4,3-b]pyridazine |
| Agrochemicals |
|---|
| Flucanozole, a fungicide |
| Others |
|---|
| Preparation of potent, selective, and orally active cyclooxygenase-2 inhibitor |
| Determination of tryptophan in proteins |
| In FTIR spectroscopy to distinguish between various N atoms based on their vibrational frequencies |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | White to off-white crystalline, hygroscopic powder |
| Solubility | – | Soluble in methanol and water |
| Melting range | °C | 79 – 87 |
| Moisture | % | Max 0.50 |
| Assay (on anhydrous basis) | % w/w | Min 99.00 |
STORAGE
Stored at ambient temperature
PACKING
40 kg HDPE drum
REACH Status
Not registered
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