INTRODUCTION
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Manufacture
It is manufactured by bromination of 4-hydroxybenzoic acid.
Synonym | Bromoxynylbenzoic acid 3,5-Dibromo-4-hydroxybenzoate |
CAS no. | 3337-62-0 |
EINECS no. | 222-075-0 |
Molecular formula | C7H4Br2O3 |
Molecular weight | 295.91 |
Structure | ![]() |
Applications
3,5-Dibromo-4-hydroxybenzoic acid is used in synthesis of the following APIs |
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Epaminurad, a URAT1 inhibitor |
Benzbromarone, an uricosuric agent |
Intermediates |
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3,5-Dibromo-4-((trimethylsilyl)oxy)benzoyl chloride |
3,5-Dibromo-4-hydroxybenzoic acid methyl ester |
Others |
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As biological stain |
As fluorescent probe to detect metal ions and proteins |
In drug delivery system |
In inhibition of Cytochrome P450 |
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | White to off white crystalline powder |
Identification by proton-NMR | – | Should conform to the structure |
Solubility | – | Soluble in chloroform / DMSO |
Melting point | °C | 271.0 – 274.0 |
Moisture | % | Max 1.0 |
Purity by HPLC | % | Min 98.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 Kg HDPE drum with inner PP bags.
REACH Status
Not registered yet.
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