INTRODUCTION

3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups.  They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.

Manufacture
It is manufactured by bromination of 4-hydroxybenzoic acid.

SynonymBromoxynylbenzoic acid
3,5-Dibromo-4-hydroxybenzoate
CAS no.3337-62-0
EINECS no.222-075-0
Molecular formulaC7H4Br2O3
Molecular weight295.91
Structure

Applications

3,5-Dibromo-4-hydroxybenzoic acid is used in synthesis of the following APIs
Epaminurad, a URAT1 inhibitor
Benzbromarone, an uricosuric agent
Intermediates
3,5-Dibromo-4-((trimethylsilyl)oxy)benzoyl chloride
3,5-Dibromo-4-hydroxybenzoic acid methyl ester
Others
As biological stain
As fluorescent probe to detect metal ions and proteins
In drug delivery system
In inhibition of Cytochrome P450

SPECIFICATIONS

TestUnitSpecification
AppearanceWhite to off white crystalline powder
Identification by proton-NMRShould conform to the structure
SolubilitySoluble in chloroform / DMSO
Melting point°C271.0 – 274.0
Moisture%Max 1.0
Purity by HPLC%Min 98.0

STORAGE
Stored at ambient temperature.

PACKING
25 Kg HDPE drum with inner PP bags.

REACH Status
Not registered yet.

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