INTRODUCTION

2-Amino-3-methylpyridine is a heterocyclic building block used in organic chemistry to manufacture API’s, intermediates, agro-chemicals, dyes, and fragrances. The chemical reactivity of the molecule is due to presence of two substituents – amino and methyl.

Manufacture
It is manufactured by ring methylation of gamma-picoline using methyl isocyanate, the byproduct being 2-amino-5-methylpyridine The 3-methyl isomer is separated by crystallization.

Synonym3-Methyl-2-pyridinamine
2-Amino-gamma-picoline
CAS no.1603-40-3
EINECS no.216-501-4
Molecular formulaC6H8N2
Molecular weight108.14
Structure

Applications

API’s
Pemirolast (anti-allergic)
Lumacaftor (treatment of cystic fibrosis)
Agrochemicals
Imidacloprid (insecticide)
Intermediates
Ethyl 2-aminopyridine-3-carboxylate
2-Amino-5-bromo-3-methylpyridine
2-(2,2,2-Trifluoromethoxy)pyridine-3-carboxylic acid
2-Amino-5-nitropyridine-3-carboxylic acid
Others
Used in proteomic research
In synthesis of nitric oxide synthase inhibitor

SPECIFICATIONS

TestUnitSpecification
AppearanceClear colorless to pale yellow liquid / semi-solid
Identification by GCRetention time of the principal peak of sample should match with that of working standard
Moisture% w/vMax 0.50
Purity by GC%Min 98.00

STORAGE
Stored at ambient temperature

PACKING
25 kg UN-approved HDPE drum

REACH Status
Not registered yet

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