INTRODUCTION
2-Amino-3-methylpyridine is a heterocyclic building block used in organic chemistry to manufacture API’s, intermediates, agro-chemicals, dyes, and fragrances. The chemical reactivity of the molecule is due to presence of two substituents – amino and methyl.
Manufacture
It is manufactured by ring methylation of gamma-picoline using methyl isocyanate, the byproduct being 2-amino-5-methylpyridine The 3-methyl isomer is separated by crystallization.
| Synonym | 3-Methyl-2-pyridinamine 2-Amino-gamma-picoline |
| CAS no. | 1603-40-3 |
| EINECS no. | 216-501-4 |
| Molecular formula | C6H8N2 |
| Molecular weight | 108.14 |
| Structure |  |
Applications
| API’s |
|---|
| Pemirolast (anti-allergic) |
| Lumacaftor (treatment of cystic fibrosis) |
| Agrochemicals |
|---|
| Imidacloprid (insecticide) |
| Intermediates |
|---|
| Ethyl 2-aminopyridine-3-carboxylate |
| 2-Amino-5-bromo-3-methylpyridine |
| 2-(2,2,2-Trifluoromethoxy)pyridine-3-carboxylic acid |
| 2-Amino-5-nitropyridine-3-carboxylic acid |
| Others |
|---|
| Used in proteomic research |
| In synthesis of nitric oxide synthase inhibitor |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to pale yellow liquid / semi-solid |
| Identification by GC | – | Retention time of the principal peak of sample should match with that of working standard |
| Moisture | % w/v | Max 0.50 |
| Purity by GC | % | Min 98.00 |
STORAGE
Stored at ambient temperature
PACKING
25 kg UN-approved HDPE drum
REACH Status
Not registered yet
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