INTRODUCTION
6-Bromopyridine-2,3-diamine is a heterocyclic organic compound belonging to the class of substituted pyridines. It is used mainly as an intermediate in pharmaceuticals and agrochemicals.
MANUFACTURE
6-Bromopyridine-2,3-diamine is obtained by reducing 6-bromo-3-nitro-2-pyridinamine under carefully controlled reaction conditions. The intermediate, 6-bromo-3-nitro-2-pyridinamine, is synthesized from the readily available 2-amino-6-chloro-3-nitropyridine through a halogen exchange reaction using hydrogen bromide in acetic acid under controlled conditions.
| Synonyms | 6-Bromo-2,3-pyridinediamine; 2,3-Diamino-6-bromopyridine |
| CAS no. | 129012-04-0 |
| EINECS no. | – |
| Molecular formula | C5H6BrN3 |
| Molecular weight | 188.03 |
| Structure |  |
APPLICATIONS
6-Bromopyridine-2,3-diamine is a valuable heterocyclic intermediate with a range of applications. Its utility comes from the presence of both reactive amine groups (-NH₂) and a bromine substituent, which allow diverse chemical transformations.
| Pharmaceutical Applications: |
| Intermediate for drug synthesis: |
| • Acts as a key building block in the synthesis of biologically active heterocycles. |
| • The diamine functionality enables formation of Imidazoles, Triazines and Quinazoline derivatives. |
| • These scaffolds are commonly found in: Anticancer agents, Antimicrobial drugs, Anti-inflammatory compounds. |
| Kinase inhibitor development: |
| • Frequently used in designing protein kinase inhibitors due to its ability to form hydrogen bonds with biological targets. |
| • The bromine atom allows further functionalization via cross-coupling reactions (e.g. Suzuki, Buchwald–Hartwig, etc.). |
| Agrochemical Applications: |
| • Serves as an intermediate in the synthesis of Herbicides, Fungicides and Insecticides. |
| • Nitrogen-rich heterocycles derived from it often show: Enhanced biological activity, Target specificity toward pests or weeds. |
| Material Science Applications: |
| • Used in the synthesis of functional organic materials and as a ligands for coordination chemistry. |
| • Potential roles include-Organic semiconductors, Dye intermediates, Polymer modifiers. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Light brown solid |
| Identification by 1H NMR | – | Complies with the product structure |
| Purity by HPLC | % | NLT 97 |
| Purity by Assay | % | NLT 97 |
| 2,3-Diamino-6-chloropyridine | % | NMT 1.5 |
STORAGE & PRECAUTION
Keep container tightly closed. Store in a cool, dry, well-ventilated area
PACKING
Globally compliant packaging
REACH Status
Not registered
ExSyn offers 6-Bromopyridine-2,3-diamine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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