INTRODUCTION
Trifluoroacetic acid (TFA) is widely used in organic synthesis as a solvent, catalyst, and reagent, owing to its reactivity and stability under adverse conditions. It is considered as one of the most economical fluorinated building blocks. It is widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group
Manufacture
Trifluoroacetic acid is commonly produced in Simon electro-fluorination process involving hydrogen fluoride and acetic acid.
| Synonyms | Trifluoroethanoic acid Perfluoroacetic acid |
| CAS no. | 76-05-1 |
| EINECS no. | 200-929-3 |
| Molecular formula | C2HF3O2 |
| Molecular weight | 114.02 |
| Structure |  |
Applications
| APIs |
|---|
| Isoflurane, a general anesthetic |
| Polythiazide, a diuretic |
| Intermediates |
|---|
| Trifluoroacetic anhydride |
| Trifluoroacetic acid alkyl esters |
| 2,2,2-Trifluoroethanol |
| Peroxytrifluoroacetic acid |
| 2-(2,2,2-Trifluoroacetylamino)pyridine |
| N[1-{6-Chloro-3-pyridinyl)methyl)-2(1H)-pyridinylidene]-2,2,2, trifluoroacetamide |
| Methyl 2-Fluoroacrylate |
| ε-caprolactam |
| Agrochemicals |
|---|
| Thiazufluron, a herbicide |
| Others |
|---|
| Introduction of CF3 group in organic molecules thereby creating CF3 building blocks |
| Olefin hydration to produce alcohols |
| Deprotection of amino group in peptide synthesis |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colourless liquid |
| Purity by titrimetry | % w/w | Min 99.90 |
| Moisture | % w/w | Max 0.05 |
| Fluoride | % w/w | Max 0.005 |
| Chloride | % w/w | Max 0.001 |
| Sulphate | % w/w | Max 0.001 |
| Identification by IC | – | The retention time of TFA peak matches with to that of standard TFA |
STORAGE
Product is stored at ambient temperature.
PACKING
35 kg / 250 kg UN-approved MS-HDPE drum
REACH STATUS
Registered
ExSyn offers TFA on commercial scale, from a REACH-registered source, and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice ! If you need any additional information or SDS, please get in touch with us.
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