INTRODUCTION
Oxalyl chloride is a colorless liquid with pungent odor. The chloride is volatile and moisture sensitive. As a useful reagent employed in a variety of chemical syntheses, it finds applications in APIs, intermediates, and agrochemicals.
Manufacture
The acid chloride is produced by chlorination of oxalic acid by using phosphorous pentachloride.
| Synonyms | Ethanedioyl dichloride Oxalic acid dichloride |
| CAS no. | 79-37-8 |
| EINECS no. | 201-200-2 |
| Molecular formula | C2Cl2O2 |
| Molecular weight | 126.93 |
| Structure |  |
Pharmaceutical Applications
Oxalyl chloride is a KRM to produce the following APIs:
| Tivantinib | anti-cancer drug |
| Diclofenac | anti-inflammatory drug |
Agrochemicals Applications
The acid chloride is also a raw material in manufacture of many plant protection products such as:
| Chinomethionat |
| Triflumuron |
| Metsulfuron |
| Bensulfuron-Methyl |
| Pyrimidine-sulfuron |
Other Vital Applications
| as catalyst in production of ketones and aldehydes from alcohols |
| as chlorinating agent to make acid chlorides from acids |
| as a reagent to convert aromatic products into corresponding acids |
| in manufacture of dioxane tetra-ketone and 2,3-dichloroquinoxaline-6-carbonyl chloride |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to pale yellow liquid |
| Purity by GC | % | Min 99.0 |
STORAGE
The product is stored at ambient temperature.
PACKING
250 kg UN approved steel drum
ExSyn offers oxalyl chloride on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.