INTRODUCTION
o-Nitrophenyl Disulfide is a chemical compound used in organic chemistry and biochemistry. It is a disulfide derivative where two o-nitrophenyl groups are connected by a disulfide bond (-S-S-). It is used in various organic synthesis reactions, as a reagent in the preparation of thiol-reactive compounds, in pharmaceutical research and laboratory applications.
Manufacture
Synthesis process typically involves dissolution of o-nitrophenyl mercaptan in an organic solvent such as dichloromethane and subsequently oxidising it using hydrogen peroxide (H2O2) or iodine. Final compound is further purified through recrystallisation.
| Synonyms | Bis(2-nitrophenyl) disulfide; 2-Nitrophenyl Disulfide; 1,2-bis(2-nitrophenyl) disulfane |
| CAS no. | 1155-00-6 |
| EINECS no. | 214-581-5 |
| Molecular formula | C12H8N2O4S2 |
| Molecular weight | 308.33 |
| Structure |  |
Applications
Its applications span across various fields of organic synthesis, biochemistry, and analytical chemistry.
| In Biochemical research to study protein modification and cross-linking of enzyme-substrate interactions or creating enzyme complexes. |
| In disulfide bond formation in proteins. |
| As a Thiol-reacting reagent help researchers analyze protein structure and interactions. |
| In organic synthesis for sulfuration and electrophilic substitution reactions. |
| Used in creation of polymer cross-links. |
| Used in the modification of synthetic rubbers or plastics. |
| In Pharmaceutical and drug discovery research it is used as a precursor in the synthesis of other disulfide-containing molecules. |
| For synthesizing functionalized aromatic compounds. |
| In analytical chemistry used as a probe to study thiol-containing molecules and in UV-Vis spectroscopic studies. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Yellow solid |
| Purity | % | Min. 98.00 |
STORAGE
Tightly closed and away from sources of ignition and heat.
PACKING
25 Kg HDPE Drums
REACH Status
Not registered
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