INTRODUCTION
N-Iodosuccinimide (NIS) is a heterocyclic organic compound. It is iodination and mild oxidation agent. In iodination reactions, NIS is preferred over molecular iodine for the ease of handling. The halogenated succinimide has various applications in organics chemistry and medical sciences.
Manufacture
It is manufactured by iodination of succinimide in aqueous caustic soda solution.
| Synonym | NIS Succiniodimide 1-Iodo-2,5-pyrrolidinedione |
| CAS no. | 516-12-1 |
| EINECS no. | 208-221-6 |
| Molecular formula | C4H4INO2 |
| Molecular weight | 224.98 |
| Structure |  |
Applications
| NIS is used as reagent in the following organics chemicals reactions: |
|---|
| Iodination of alkenes to form iodoalkanes |
| Conversion of thioglyconate to 1-hydroxy glyconate |
| Preparation of vinyl sulphones from olefins |
| Oxidative cleavage of vicinal, mono-protected diols |
| Oxidation of tosylhydrazine |
| Iodination of C-5 positions of dialkoxypyrimidines and uracils |
| Preparation of 4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine |
| Oxidative conversion of sulphur compounds |
| N-iodosuccinimide also finds use in medical sciences. It is used in study of metabolism of drugs and other compounds in cell culture. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to slightly tan crystalline powder |
| Melting range | °C | 198.0 – 206.0 |
| LOD at 60 °C, 3 hours | % | Max 0.1 |
| NBS content | % | Max 0.3 |
| Assay | % | Min 99.5 |
STORAGE
Stored at ambient temperature
PACKING
25 kg UN-approved HDPE drum
REACH Status
Not registered yet
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