INTRODUCTION
n-Butyllithium is a colorless, organic liquid. It belongs to the organometallic category of compounds. It participates in a variety of chemical reactions and acts diversly as lithiation, alkylation, metalating, and deprotonation agent. Commercially, it is offered as a solution in a hydrocarbon solvent.
Manufacture
The organometallic is manufactured by reaction between n-butyl chloride and metallic lithium in hydrocarbon, normally hexane.
| Synonyms | Butyllithium Lithium-1-butanide |
| CAS no. | 109-72-8 |
| EINECS no. | 203-698-7 |
| Molecular formula | C4H9Li |
| Molecular weight | 64.06 |
| Structure |  |
Applications
| APIs |
|---|
| Perhexiline, an anti-anginal drug |
| Intermediates |
|---|
| 3,4,5-Trichlorothiophene-2-carbonyl chloride |
| 2,4,6-Trichlorobenzoic acid |
| Ethyl 5-chlorothiophene-2-carboxylate |
| Tetrafluoro-p-methylbenzyl alcohol |
| A number of boronic acids such as: – 2,3-Difluorophenylboronic acid – 2-Bromopyridine-3-yl-boronic acid |
| Others |
|---|
| as anionic polymerization initiator |
| in manufacture of polybutadiene and isoprene rubber |
| in production of essence and pesticides |
| used in making liquid crystals |
| as reagent in metal halogen exchange reactions |
SPECIFICATIONS (n-BuLi 1.6 M in Hexane)
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear to slightly hazy pale-yellow liquid |
| Solubility | – | Soluble in hexane, benzene and toluene |
| Density @ 20 °C | g/ml | 0.670 – 0.690 |
| Molarity | M | Min 1.6 |
| Assay by chemical analysis | % | Min 15.0 |
SPECIFICATIONS (n-BuLi 2.5 M in Hexane)
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Yellow clear transparent liquid |
| Concentration | M | 2.980 – 2.520 |
| Basic impurity (n-butoxy) | mol/L | Max 0.1 |
| Total lithium content | % | 23.6 – 24.4 |
STORAGE
Stored at 2-8 °C
PACKING
1.6 M solution – 280 kg cylinder
2.5 M solution – 300 kg cylinder
REACH Status
Not registered yet
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