INTRODUCTION
Methyl magnesium chloride is the simplest of Grignard’s reagents. The neat molecule is sensitive to air and moisture. Therefore, it is offered as solution in THF with variable molarity values. At low temperature, it may crystallize out as THF complex and regain solution form at ambient temperature.
Manufacture
The product is manufactured by reaction of chloromethane with magnesium in anhydrous diethyl ether. The synthesis generally requires presence of an initiator.
| Synonyms | Methyl (chloro) magnesium Magnesium carbanide chloride |
| CAS no. | 676-58-4 |
| EINECS no. | 211-629-7 |
| Molecular formula | CH3MgCl |
| Molecular weight | 74.79 |
| Structure |  |
Applications
| APIs |
|---|
| Ganaxolone, a synthetic neuroactive steroid |
| Medetomidine, a sedative veterinary |
| Chlorphenoxamine, an anticholinergic |
| Clemastine, an antihistamine |
| Intermediates |
|---|
| Dimethyl magnesium |
| Tetramethyl lead |
| Tetramethyl tin |
| Bis(cyclopentadienyl)dimethyl titanium |
| Styrallyl alcohol |
| 2,6-Dimethyl-2-heptanol |
| Dimethyl phenethyl carbinol |
| Flavors & Fragrances |
|---|
| Hydroxycitronellal, an odorant with floral fragrance |
| Propenyl guaethol, flavor ingredient with vanilla odor |
| Others |
|---|
| Selective methylation agent for aldehydes, ketones, and carbonyls in organic syntheses |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Dark brown to grey coloured liquid |
| Molarity | M | 2.90 – 3.30 |
| Sedimentation | % | Max 2.0 |
STORAGE
Stored at ambient temperature under nitrogen blanket
PACKING
190 kg UN approved HDPE drums
REACH Status
Not registered yet
ExSyn offers methyl magnesium chloride on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.