INTRODUCTION
L-Alpha glycerylphosphorylcholine (alpha-GPC or choline alfoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerol-1-phosphate is used to support cellular membranes.
Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. It is currently the best cholinergic for increasing plasma and brain choline levels.
Manufacture
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well as from purified sunflower lecithin.
| Synonyms | Choline glycerophosphate L-α-Phosphatidylcholine |
| CAS no. | 28319-77-9 |
| EINECS no. | 248-962-2 |
| Molecular formula | C8H20NO6P |
| Molecular weight | 257.22 |
| Structure |  |
Applications
| Alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory. |
| Alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA). |
| Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off white hygroscopic powder |
| Identification – TLC | – | Standard solution and test solution same spot, RF |
| Specific Optical Rotation | – | -2.4° ~ 2.8° |
| Water content | % | NMT 2.00 |
| pH | – | 4.5 to 7.0 |
| Assay | % | 98.50 – 100.00 |
| Chemical Tests | ||
| Sulfate | % | NMT 0.02 |
| Chloride | % | NMT 0.02 |
| Related substance | – | Spot not bigger than standard solution spot |
| Residual solvent | % | NMT 0.5 |
| Heavy metals | ppm | NMT 10.00 |
STORAGE
Store in an airtight and light resistant container, away from moisture.
PACKING
5 kg HDPE drum.
REGISTRATION / CERTIFICATION
ISO, FSSAI, HACCP, HALAL, KOSHER & GMP certified.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
N,N′-Dimethylethylenediamine (DMEDA) is an organic chemical compound belonging to the diamine family. It contains two nitrogen atoms, each bearing a methyl group, connected by a two-carbon chain.
FerroQuant™ Pro is a water-soluble chromogenic reagent widely used for the spectrophotometric determination of iron. Chemically, it is a ferroin-type ligand that forms a stable, intensely colored complex with ferrous ions (Fe²⁺).
N-Vinylformamide (NVF) is a vinyl-functionalized amide and an important monomer used in the production of poly(N-vinylformamide) (PNVF). NVF is valued for its ability to undergo polymerization, producing polymers with useful water solubility, film-forming properties, and functional groups suitable for further chemical modification.
Diacetone Alcohol (DAA) is an aliphatic hydroxy ketone produced through the base-catalysed aldol addition of two acetone molecules. It contains both ketone and tertiary hydroxyl functionalities, offering excellent solvency and chemical reactivity.
As a high-boiling oxygenated solvent and valuable chemical intermediate, DAA finds broad application in paints and coatings, printing inks, adhesives, industrial cleaning, cosmetics, and textiles. It is also used as an intermediate in the production of mesityl oxide and MIBK. (4-methylpentan-2-one).
Kojic acid is a natural fungal metabolite produced through natural fermentation of carbohydrates. It works primarily as a tyrosinase inhibitor, suppressing melanin production to help reduce dark spots and even out skin tone. It also delivers antioxidant benefits, neutralizing free radicals and protecting skin cells from oxidative stress. With its naturally weak acidic profile, kojic acid is a multifunctional ingredient suited for brightening and protective skincare formulations.
(S)-Oxetan-2-yl-methanamine is a chiral oxetane-containing primary amine. The compound features a strained four-membered oxetane ring and an aminomethyl substituent, making it a valuable building block in modern medicinal chemistry. Due to its unique physicochemical properties, including increased polarity and metabolic stability compared with conventional alkyl groups, it is widely employed as an advanced pharmaceutical intermediate in drug discovery and development programs.
Guanidine carbonate is a white, crystalline, water-soluble compound with an alkaline and ionic nature. Composed of guanidinium cations and carbonate anions, it offers chemical stability, buffering capacity, and good formulation compatibility. In textile applications, it is used in formulations and fabric treatments for its thickening, softening, lubricating, anti-static, and flame-retardant properties, contributing to improved fabric finish and performance.
Tin(II) sulfide (SnS) has emerged as a safe and sustainable semiconductor owing to its non-toxicity, low cost, and natural abundance. It has attracted significant interest for solar energy conversion in thin-film photovoltaic devices because of its suitable band gap, which is approximately 1.3 eV in the orthorhombic phase and 1.5-1.7 eV in the cubic phase. In addition to photovoltaic applications, SnS is used in solid-state lubricants, near-infrared detectors, Lithium-ion batteries, and various sensing devices.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.