INTRODUCTION
L-Alpha glycerylphosphorylcholine (alpha-GPC or choline alfoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerol-1-phosphate is used to support cellular membranes.
Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. It is currently the best cholinergic for increasing plasma and brain choline levels.
Manufacture
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well as from purified sunflower lecithin.
| Synonyms | Choline glycerophosphate L-α-Phosphatidylcholine |
| CAS no. | 28319-77-9 |
| EINECS no. | 248-962-2 |
| Molecular formula | C8H20NO6P |
| Molecular weight | 257.22 |
| Structure |  |
Applications
| Alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory. |
| Alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA). |
| Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off white hygroscopic powder |
| Identification – TLC | – | Standard solution and test solution same spot, RF |
| Specific Optical Rotation | – | -2.4° ~ 2.8° |
| Water content | % | NMT 2.00 |
| pH | – | 4.5 to 7.0 |
| Assay | % | 98.50 – 100.00 |
| Chemical Tests | ||
| Sulfate | % | NMT 0.02 |
| Chloride | % | NMT 0.02 |
| Related substance | – | Spot not bigger than standard solution spot |
| Residual solvent | % | NMT 0.5 |
| Heavy metals | ppm | NMT 10.00 |
STORAGE
Store in an airtight and light resistant container, away from moisture.
PACKING
5 kg HDPE drum.
REGISTRATION / CERTIFICATION
ISO, FSSAI, HACCP, HALAL, KOSHER & GMP certified.
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