INTRODUCTION
4-(Dimethylamino)pyridine (DMAP) is an efficient and versatile acylation catalyst. Besides, it find uses in other chemical reactions as well as in production of APIs, agrochemicals, and intermediates.
Manufacture
The product is commercially manufactured by methylation of 4-pyridinamine. Alternatively, it is produced by ammonolysis of 4-hydroxypyridine followed by the methylation.
| Synonyms | ɣ-(Dimethylamino)pyridine N,N-Dimethyl-4-pyridinamine |
| CAS no. | 1122-58-3 |
| EINECS no. | 214-353-5 |
| Molecular formula | C7H10N2 |
| Molecular weight | 122.17 |
| Structure |  |
Applications in APIs
| DMAP is consumed in production of APIs such as: |
|---|
| Abacavir (nucleoside reverse transcriptase inhibitor) |
| Lamivudine (anti-HIV) |
| Zidovudine (anti-HIV) |
| Ivacaftor (Cystic Fibrosis Treatment) |
| Montelukast (anti-Asthma) |
| Docetaxel (anti-Cancer) |
| Paclitaxel (anti-Caner, antineoplastic) |
| Rosuvastatin (anti-Cholesterol) |
| Alfentanil (Analgesic) |
| Carfentanil (Analgesic) |
| Cladribine (anti-Leukemia) |
Applications in Agrochemicals
| The dimethylated pyridine is used to produce agrochemicals: |
|---|
| Chlorpyriphos (Insecticide) |
| Clethodim (Herbicide) |
| Sethoxidim (Herbicide) |
Applications in Intermediates
| DMAP is also a KRM for the synthesis of the following intermediates: |
|---|
| N,N-Dimethyl-1-(2,4,6-trinitrophenyl)pyridin-1-ium-4-amine chloride |
| N,N-Dimethylpiperidin-4-amine |
Other Uses
It also acts as a catalyst in some alkylation, etherification, and esterification reactions.
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off-white crystalline solid |
| Identifications by GC | – | Retention time of the major peak matches with that of the reference standard |
| Melting range | °C | 111-114 |
| Moisture by KF | % w/w | Max 0.1 |
| Purity by GC | % | Min 99.00 |
| Assay by chemical method | % | Min 99.00 |
STORAGE
The product is stored at ambient temperature.
PACKING
25 kg fibre drum.
REACH Status
DMAP offered by ExSyn is registered under EU REACH regulations.
ExSyn offers DMAP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Kojic acid is a natural fungal metabolite produced through natural fermentation of carbohydrates. It works primarily as a tyrosinase inhibitor, suppressing melanin production to help reduce dark spots and even out skin tone. It also delivers antioxidant benefits, neutralizing free radicals and protecting skin cells from oxidative stress. With its naturally weak acidic profile, kojic acid is a multifunctional ingredient suited for brightening and protective skincare formulations.
(S)-Oxetan-2-yl-methanamine is a chiral oxetane-containing primary amine. The compound features a strained four-membered oxetane ring and an aminomethyl substituent, making it a valuable building block in modern medicinal chemistry. Due to its unique physicochemical properties, including increased polarity and metabolic stability compared with conventional alkyl groups, it is widely employed as an advanced pharmaceutical intermediate in drug discovery and development programs.
Guanidine carbonate is a white, crystalline, water-soluble compound with an alkaline and ionic nature. Composed of guanidinium cations and carbonate anions, it offers chemical stability, buffering capacity, and good formulation compatibility. In textile applications, it is used in formulations and fabric treatments for its thickening, softening, lubricating, anti-static, and flame-retardant properties, contributing to improved fabric finish and performance.
Tin(II) sulfide (SnS) has emerged as a safe and sustainable semiconductor owing to its non-toxicity, low cost, and natural abundance. It has attracted significant interest for solar energy conversion in thin-film photovoltaic devices because of its suitable band gap, which is approximately 1.3 eV in the orthorhombic phase and 1.5-1.7 eV in the cubic phase. In addition to photovoltaic applications, SnS is used in solid-state lubricants, near-infrared detectors, Lithium-ion batteries, and various sensing devices.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.