INTRODUCTION
Caffeine (anhydrous) is a naturally occurring methylxanthine derivative used as a CNS stimulant, to restore mental alertness and wakefulness in patients experiencing fatigue or drowsiness.
Manufacturing
Caffeine anhydrous is made from the seeds and leaves of green coffee plants. The word “anhydrous” means “without water.” After harvesting, caffeine is extracted from the plant matter and dehydrated. This produces a highly concentrated caffeine powder.
| Synonyms | Methyltheobromine 1,3,7-Trimethylxanthine |
| CAS no. | 58-08-2 |
| EINECS no. | 200-362-1 |
| Molecular formula | C8H10N4O2 |
| Molecular weight | 194.19 |
| Structure |  |
Applications
| Caffeine anhydrous is used as stimulant drug in |
|---|
| Food production |
| Beverage such as in coffee, tea, soda drink to stimulate the central nervous |
| Pharmaceutical |
| In Health and Personal care |
|---|
| Caffeine anhydrous is used as Fragrance Ingredient; Skin-Conditioning agent. |
| Primary short-term effects of Caffeine are: |
|---|
| Increasing resting heart rate |
| Psychostimulation |
| Constricting blood vessels |
| Dilating the bronchioles |
| Slightly increasing metabolic rate |
| Increasing urine production and gastric motility |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Description | – | A white crystalline powder; sublimes readily |
| Solubility | – | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol and in ether. It dissolves in concentrated solutions of alkali benzoates or salicylates. |
| Identification A | – | By IR absorption identical with Std. |
| Identification B | – | To Comply |
| Water | % | NMT 0.5 |
| Melting Range | °C | Between 235.0 – 237.5 after drying at 80°C for 4 hours |
| Residue on Ignition | % | NMT 0.1 |
| Arsenic | ppm | NMT 3.0 |
| Heavy Metals | % | NMT 0.001 |
| Readily Carbonizable Substances | – | The solution has no more color than matching Fluid D. |
| Residual solvents | – | To Comply |
| Other Alkaloids | – | No precipitate is formed |
| Chromatographic Purity – Any individual impurity | % | NMT 0.1 |
| Total impurity | % | NMT 0.1 |
| Assay | % | NLT 98.5 & NMT 101.0 on anhydrous basis |
STORAGE
Store in a cool, dry, well-ventilated area.
PACKING
25 kg drum.
REGISTRATION / CERTIFICATION
ISO, FSSAI, HALAL, KOSHER, GMP & US-DMF.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Nikethamide is a synthetic organic compound derived from nicotinic acid (vitamin B₃). It consists of a pyridine ring linked to a diethyl amide functional group and belongs to the class of pyridine amide derivatives.
(2-Methoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide is a stabilized phosphonium salt widely used as an intermediate in organic synthesis. Due to presence of an ester group, the compound generates a stabilized ylide that is particularly useful for synthesizing α, β-unsaturated esters, valuable intermediates in pharmaceuticals, agrochemicals, fragrances, and fine chemicals.
p-tert-Butylphenol (PTBP), is an aromatic organic compound consists of a phenol ring substituted with a tert-butyl group at the para (4-) position, giving it improved thermal stability and hydrophobic properties compared to phenol. PTBP features significant hydrogen bonding capabilities, which enhance its solubility in organic solvents. PTBP is used primarily as an intermediate in the manufacturing of polycarbonate plastics, phenolic resins, and epoxy resins.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.