INTRODUCTION
4-Methoxypyridine, a molecule with ether function, is a reactive base. Its nitrogen atom is activated by the methoxy group. It renders the molecule active and thus 4-methoxypyrimidine participates in many chemical processes. Its uses are in intermediates, in synthesis of biologically active moieties, and in proteomic research.
Manufacture
The compound is produced by ether formation reaction between methanol and 4-bromopyridine. Alternative synthesis route is catalytic hydrogenation of 4-methoxypyridine-N-oxide.
| Synonyms | p-Methoxypyridine Methyl pyridin-4-yl ether |
| CAS no. | 620-08-6 |
| EINECS no. | 210-624-7 |
| Molecular formula | C6H7NO |
| Molecular weight | 109.13 |
| Structure |  |
Applications in Proteins
In proteomic research, 4-methoxypyridine is used in synthesis of benzoylated N-ylides, which in turn act as protein farnesyltransferase inhibitor.
Applications in Intermediates
Amongst few others, the following intermediates are manufactured from 4-methoxypyridine:
| (4-methoxpyridin-3-yl)trimethylsilane |
| 2-Iodo-3-methoxypyridine |
| 4-Methoxy-3-(trimethylstannyl)pyridine |
| 2-Bromo-6-methoxypyridine |
| 2-Bromo-4-methoxy-3-pyridinamine |
| 4-Methoxypiperidine |
Other Applications
| As building block for synthesis of some biologically active compounds |
| Its o-lithiated derivative used as metalating base in synthetic chemistry |
| As a starting reagent for stereo-controlled synthesis of (±)-pumiliotoxin C and (±)-lasubine II |
| In efficient construction of dihyropyridin-4-ones, which in turn serve as potential ligands for neuronal nicotinic acetycholine receptors |
| As flavoring agent in food |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear colorless to pale yellow liquid |
| Moisture by KF | % | Max 0.5 |
| Purity by GC | % | Min 97 |
STORAGE
The product is stored at ambient temperature.
PACKING
180 kg Composite drum.
REACH Status
Not registered yet.
ExSyn offers 4-Methoxypyridine on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Choline salicylate is a salicylate salt formed from choline and salicylic acid. It is a non-steroidal anti-inflammatory agent (NSAID-type compound) mainly used for its analgesic, anti-inflammatory, and mild antiseptic properties. Unlike acetylated salicylates, it is less irritating to the gastric mucosa and is commonly used in topical oral preparations such as gels and mouth paints.
TensyraTM N-10 (Octoxinol 10; tert-octyl phenyl ethoxylate) is a non-ionic surfactant known for its excellent solubilizing and membrane-permeabilizing properties. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.It readily breaks down biological membranes to lyse cells, solubilize proteins, and permeabilize cell membranes for assays.
Teprenone (Geranylgeranylacetone, GGA) is a mixture of the all-trans and mono-cis isomers of 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one (in a weight ratio of 3:2). It is an acyclic isoprenoid compound with a structure like retinoids and is widely used for the treatment of gastrointestinal ulcers.
Ciclopirox Olamine (CPO) is the N-oxide of a 2 -hydroxy pyridine derivative that carries antifungal, antibacterial, and anti-inflammatory properties. It is composed of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone combined with 2 aminoethanol (olamine) in a 1:1 ratio.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.