INTRODUCTION
2-Amino-p-cresol is a crystalline, sublime solid soluble in oxygenated solvents. It serves as an important starting material for production of colorants and other intermediates.
Manufacture
The compound is produced by nitration of p-cresol and subsequent reduction of the nitro-p-cresol.
| Synonyms | 3-Amino-4-hydroxytoluene 2-Amino-4-methylphenol |
| CAS no. | 95-84-1 |
| EINECS no. | 202-457-3 |
| Molecular formula | C7H9NO |
| Molecular weight | 123.16 |
| Structure |  |
Applications in Colorants
The aromatic compound is used to produce colorants such as:
| Fluorescent Brightener 135 |
| Fluorescent Brightener PF |
| Reactive Blue 40 |
| Mordant Green 10 |
Applications in Intermediates
2-Amino-p-cresol can be converted into the following versatile intermediates:
| 4-(2-Hydroxy-5-methylphenyl)imino-2-pentanone |
| N-(2-Hydroxy-5-methylphenyl)-N’-phenylurea |
| 2-Mercapto-5-methylbenzoxazole |
| 2,5-Dimethylbenzoxazole |
| 4-Acetoxy-3-acetyaminotoluene |
Other Applications
| In synthesis of functionalized spiropyran of benzoxazonone series |
| As major sensitizer in contact allergy to Disperse Yellow 3 |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear crystalline powder or crystals with characteristic odor |
| Solubility in 1% methanol solution | – | Solution should be clear and light color |
| Identification by HPLC | – | Should conform to reference chromatogram |
| Water content | % | Max 1.5 |
| Sulphated Ash | % | Max 1.5 |
| Related substances by HPLC | ||
| a. 2,6-diaminomethyl-4-phenol | % | Max 0.2 |
| b. 4-Methyl-3-aminophenol | % | Max 0.1 |
| c. Any other impurity | % | Max 0.1 |
| d. Total impurities | % | Max 0.5 |
| Assay by titration | % | Min 97 |
STORAGE
The product is stored under inert atmosphere at ambient temperature.
PACKING
25 kg HDPE drum
ExSyn offers 2-amino-p-cresol on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.