INTRODUCTION
2-Amino-p-cresol is a crystalline, sublime solid soluble in oxygenated solvents. It serves as an important starting material for production of colorants and other intermediates.
Manufacture
The compound is produced by nitration of p-cresol and subsequent reduction of the nitro-p-cresol.
| Synonyms | 3-Amino-4-hydroxytoluene 2-Amino-4-methylphenol |
| CAS no. | 95-84-1 |
| EINECS no. | 202-457-3 |
| Molecular formula | C7H9NO |
| Molecular weight | 123.16 |
| Structure |  |
Applications in Colorants
The aromatic compound is used to produce colorants such as:
| Fluorescent Brightener 135 |
| Fluorescent Brightener PF |
| Reactive Blue 40 |
| Mordant Green 10 |
Applications in Intermediates
2-Amino-p-cresol can be converted into the following versatile intermediates:
| 4-(2-Hydroxy-5-methylphenyl)imino-2-pentanone |
| N-(2-Hydroxy-5-methylphenyl)-N’-phenylurea |
| 2-Mercapto-5-methylbenzoxazole |
| 2,5-Dimethylbenzoxazole |
| 4-Acetoxy-3-acetyaminotoluene |
Other Applications
| In synthesis of functionalized spiropyran of benzoxazonone series |
| As major sensitizer in contact allergy to Disperse Yellow 3 |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear crystalline powder or crystals with characteristic odor |
| Solubility in 1% methanol solution | – | Solution should be clear and light color |
| Identification by HPLC | – | Should conform to reference chromatogram |
| Water content | % | Max 1.5 |
| Sulphated Ash | % | Max 1.5 |
| Related substances by HPLC | ||
| a. 2,6-diaminomethyl-4-phenol | % | Max 0.2 |
| b. 4-Methyl-3-aminophenol | % | Max 0.1 |
| c. Any other impurity | % | Max 0.1 |
| d. Total impurities | % | Max 0.5 |
| Assay by titration | % | Min 97 |
STORAGE
The product is stored under inert atmosphere at ambient temperature.
PACKING
25 kg HDPE drum
ExSyn offers 2-amino-p-cresol on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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