INTRODUCTION
Triphenylphosphine is a common organophosphorus compound that is frequently abbreviated as PPh3 or Ph3P. It is widely used in organic and organometallic compound synthesis because it is an effective reducing agent as well as a neutral ligand. At room temperature, PPh3 crystals are relatively air-stable and colourless.
MANUFACTURE
The industrial synthesis involves the reaction between phosphorus trichloride, chlorobenzene, and sodium.
| Synonym | Triphenylphosphane,Phosphorus triphenyl |
| CAS no. | 603-35-0 |
| EINECS no. | 210-036-0 |
| Molecular formula | C18H15P |
| Molecular weight | 262.29 g/mol |
| Structure |  |
| APPLICATIONS |
|---|
| Triphenylphosphine is used in the synthesis of Chlorambucil, which has been shown to be cytotoxic in breast and pancreatic cancers. |
| It is also used to make -Tocopherol analogues for monitoring antioxidant status. |
| Used in the synthesis of Vitamin D2, Vitamin A, Clindamycin, and other drugs. |
| Also, used in a variety of applications, including sensitizers, heat stabilizers, light stabilizers, antioxidants, flame retardants, antistatic agents, rubber antiozonants, and analytical reagents. |
| The Wittig reaction, which converts aldehydes and ketones to alkenes, was Ph3P’s first significant use in organic synthesis. |
| Triphenylphosphine is also used as a transition metal-ligand in olefin polymerizations and in the Suzuki, Mitsunobu, and Appel reactions. |
| In homogeneous catalysis, triphenylphosphine is a standard ligand. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Description | – | A white to off white crystalline powder or flakes |
| Solubility | – | Soluble in toluene |
| Melting range | °C | 78.0 to 83.0 |
| Loss on drying | % w/w | Not more than 0.5 |
| Assay (by chemical) | % | Not less than 99.0 |
PACKING
25 kg HDPE bag.
STORAGE
Store in a dry and well-ventilated place.
REACH
Not registered.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Yttrium oxide (Y2O3), also known as yttria, is an air-stable, odorless white powder. It is a highly stable, chemically inert ceramic with a very high melting point. It is insoluble in water but readily dissolves in most strong acids. Increasing the specific surface area and porosity of Y2O3 can further improve its relevant physical and chemical properties.
Ethyl 7,7,7-trifluoro-3-hydroxy-3-methylheptanoate is a fluorinated aliphatic hydroxy ester. The presence of the trifluoromethyl group imparts enhanced metabolic stability, lipophilicity, and unique physicochemical properties compared with non-fluorinated analogues. This compound is primarily used as a synthetic intermediate in pharmaceutical and agrochemical research.
2-Chloro-1,1,1-trimethoxyethane is an organochlorine orthoester compound commonly used as a versatile synthetic intermediate in organic and pharmaceutical chemistry. It is a colorless to pale yellow liquid with good reactivity toward nucleophilic substitution and cyclization reactions, making it valuable in the preparation of heterocyclic and bioactive molecules.
Glycolaldehyde dimer is the cyclic dimeric form of glycolaldehyde, the simplest hydroxyaldehyde. Glycolaldehyde is often supplied as stable dimeric solid, commonly identified as 2,5-dihydroxy-1,4-dioxane.
N,N-Diisopropylethylamine (DIPEA), also known as Hünig’s Base, is a sterically hindered tertiary amine. It is a colorless liquid with a strong amine odor and is widely used as a low nucleophilic organic base in pharmaceutical, agrochemical, and fine chemical synthesis. Due to its bulky structure, DIPEA effectively scavenges acids without participating in unwanted side reactions.
Tris(2,4-di-tert-butylphenyl) phosphite (TDPP) often recognized commercially as Irgafos 168 is a high-performance organophosphorus compound primarily utilized as secondary antioxidant and processing stabilizer. Its characteristic to undergo metallation reaction and provide a cost-effective synthetic processes allows it to be useful in biaryl coupling reactions.
Undecylenic acid is an unsaturated fatty acid naturally derived from castor oil. It is a colorless to pale yellow liquid with antifungal and antimicrobial properties. Chemically known as 10-undecenoic acid, it contains an 11-carbon chain with one double bond and is widely used in pharmaceuticals
5-Nitro Isophthalic Acid (5-NIPA) is an aromatic organic compound derived from isophthalic acid. The presence of two carboxylic acid groups along with a nitro substituent at the 5-position makes it a valuable intermediate in the manufacture of fine chemicals, pharmaceuticals, dyes, pigments, and advanced materials.
Trichloroacetonitrile is a halogenated organic compound belonging to nitrile family. Its strong electrophilic character makes it a valuable intermediate in organic synthesis. It readily undergoes hydrolysis, particularly under acidic or basic conditions, yielding trichloroacetamide and related derivatives.