INTRODUCTION
4-(Dimethylamino)pyridine (DMAP) is an efficient and versatile acylation catalyst. Besides, it find uses in other chemical reactions as well as in production of APIs, agrochemicals, and intermediates.
Manufacture
The product is commercially manufactured by methylation of 4-pyridinamine. Alternatively, it is produced by ammonolysis of 4-hydroxypyridine followed by the methylation.
Synonyms | ɣ-(Dimethylamino)pyridine N,N-Dimethyl-4-pyridinamine |
CAS no. | 1122-58-3 |
EINECS no. | 214-353-5 |
Molecular formula | C7H10N2 |
Molecular weight | 122.17 |
Structure | ![]() |
Applications in APIs
DMAP is consumed in production of APIs such as: |
---|
Abacavir (nucleoside reverse transcriptase inhibitor) |
Lamivudine (anti-HIV) |
Zidovudine (anti-HIV) |
Ivacaftor (Cystic Fibrosis Treatment) |
Montelukast (anti-Asthma) |
Docetaxel (anti-Cancer) |
Paclitaxel (anti-Caner, antineoplastic) |
Rosuvastatin (anti-Cholesterol) |
Alfentanil (Analgesic) |
Carfentanil (Analgesic) |
Cladribine (anti-Leukemia) |
Applications in Agrochemicals
The dimethylated pyridine is used to produce agrochemicals: |
---|
Chlorpyriphos (Insecticide) |
Clethodim (Herbicide) |
Sethoxidim (Herbicide) |
Applications in Intermediates
DMAP is also a KRM for the synthesis of the following intermediates: |
---|
N,N-Dimethyl-1-(2,4,6-trinitrophenyl)pyridin-1-ium-4-amine chloride |
N,N-Dimethylpiperidin-4-amine |
Other Uses
It also acts as a catalyst in some alkylation, etherification, and esterification reactions.
SPECIFICATIONS
Test | Unit | Specification |
---|---|---|
Appearance | – | White to off-white crystalline solid |
Identifications by GC | – | Retention time of the major peak matches with that of the reference standard |
Melting range | °C | 111-114 |
Moisture by KF | % w/w | Max 0.1 |
Purity by GC | % | Min 99.00 |
Assay by chemical method | % | Min 99.00 |
STORAGE
The product is stored at ambient temperature.
PACKING
25 kg fibre drum.
REACH Status
DMAP offered by ExSyn is registered under EU REACH regulations.
ExSyn offers DMAP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
The product, acronymed Oct-NBE, is an organic compound with a cyclic ring system and a 8-membered hydrophobic chain. The structure renders the chemical special properties leading to its applications in diverse fields.
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.
The product, acronymed ETD, is an organic compound with a fused bicyclic ring system and an ethylidene group. The structure renders the chemical special properties leading to its applications in diverse fields.
Sodium perchlorate monohydrate is the inorganic compound with the chemical formula NaClO4•H2O. It is the common existence form of sodium perchlorate, which can gradually absorb water in the air to form the monohydrate. Sodium perchlorate monohydrate is white rhombic crystal which is highly soluble in water and in alcohol. Its capacity to undergo redox reactions, liberating oxygen atoms, has been harnessed in the preparation of specialty chemicals, including pharmaceutical intermediates and fine chemicals.
Triphenylphosphine is a common organophosphorus compound that is frequently abbreviated as PPh3 or Ph3P. It is widely used in organic and organometallic compound synthesis because it is an effective reducing agent as well as a neutral ligand. At room temperature, PPh3 crystals are relatively air-stable and colourless.
Potassium chlorate holds significant importance across various industries due to its diverse applications. This white crystalline compound has been utilized for centuries as an essential ingredient in the production of matches, fireworks, and explosives, owing to its ability to release oxygen upon decomposition.
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It is an organic heterotetracyclic compound that has a Furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
Octadecylphosphonic acid (ODPA), a versatile chemical compound, serves as a surfactant and dispersant in applications spanning coatings, lubricants, and corrosion inhibition. With its hydrophobic octadecyl chain linked to a phosphonic acid group, it excels in surface modification, boosting adhesion in metal surfaces.
2-(Benzylmethylamino)-1-phenylpropanone is an organics intermediate from ketone category. It is a compound with notable pharmacological potential and itself has excellent cytotoxic properties. In trade, the chemicals is referred to as AMK.