INTRODUCTION
2-Amino-p-cresol is a crystalline, sublime solid soluble in oxygenated solvents. It serves as an important starting material for production of colorants and other intermediates.
Manufacture
The compound is produced by nitration of p-cresol and subsequent reduction of the nitro-p-cresol.
| Synonyms | 3-Amino-4-hydroxytoluene 2-Amino-4-methylphenol |
| CAS no. | 95-84-1 |
| EINECS no. | 202-457-3 |
| Molecular formula | C7H9NO |
| Molecular weight | 123.16 |
| Structure |  |
Applications in Colorants
The aromatic compound is used to produce colorants such as:
| Fluorescent Brightener 135 |
| Fluorescent Brightener PF |
| Reactive Blue 40 |
| Mordant Green 10 |
Applications in Intermediates
2-Amino-p-cresol can be converted into the following versatile intermediates:
| 4-(2-Hydroxy-5-methylphenyl)imino-2-pentanone |
| N-(2-Hydroxy-5-methylphenyl)-N’-phenylurea |
| 2-Mercapto-5-methylbenzoxazole |
| 2,5-Dimethylbenzoxazole |
| 4-Acetoxy-3-acetyaminotoluene |
Other Applications
| In synthesis of functionalized spiropyran of benzoxazonone series |
| As major sensitizer in contact allergy to Disperse Yellow 3 |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Clear crystalline powder or crystals with characteristic odor |
| Solubility in 1% methanol solution | – | Solution should be clear and light color |
| Identification by HPLC | – | Should conform to reference chromatogram |
| Water content | % | Max 1.5 |
| Sulphated Ash | % | Max 1.5 |
| Related substances by HPLC | ||
| a. 2,6-diaminomethyl-4-phenol | % | Max 0.2 |
| b. 4-Methyl-3-aminophenol | % | Max 0.1 |
| c. Any other impurity | % | Max 0.1 |
| d. Total impurities | % | Max 0.5 |
| Assay by titration | % | Min 97 |
STORAGE
The product is stored under inert atmosphere at ambient temperature.
PACKING
25 kg HDPE drum
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