INTRODUCTION
(S)-(+)-Glycidyl p-toluenesulphonates is an organic chemical in the class of epoxide and it is a chiral molecule. Its reactivity is due to presence of active epoxide moiety and thus it undergoes various transformation reactions leading to syntheses of chiral intermediates and biologically active products.
Manufacture
The chiral compound is manufactured by the reaction of tosyl chloride with S-glycidol. The resultant ester is treated with a strong base to obtain the desired product.
| Synonym | (2S)-(+)-Glycidyl tosylate (S)-Glycidyl tosylate |
| CAS no. | 70987-78-9 |
| EINECS no. | 417-210-7 |
| Molecular formula | C10H12O4S |
| Molecular weight | 228.26 |
| Structure |  |
| Applications |
|---|
| Enantioselective synthesis of 4-acetyl-3-hydroxymethyl-3,4-dihydro-2H-pyrido [3,3-b] oxazine |
| In synthesis of 1-O-hexadecyl-2-O-benzyl-sn-glycerol 3-O-p-toluenesuplhonte |
| As a reagent in production of chiral molecules and chiral intermediates for APIs such as: # (S)-2-Oxiranylanisole # S)-2-((3-Chlorophenoxy)methyl)oxirane |
| As building block for polymers and other materials |
| In synthesis of peptides, peptidomimetics, and other biological active substances |
| As an intermediate to synthesize neurochemicals |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off-white crystalline powder |
| Specific rotation, (C=2.75 CHCl3) | – | +17 to +19 |
| LOD | % | Max 1.0 |
| Melting point | °C | 45.0 – 48.0 |
| Assay by GC | % | Min 98.0 |
| Enantiomeric excess by HPLC | ee% | Min 99.0 |
STORAGE
2 to 8 °C
PACKING
25 kg drum
REACH Status
Not registered yet
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