INTRODUCTION

(S)-(+)-Glycidyl p-toluenesulphonates is an organic chemical in the class of epoxide and it is a chiral molecule. Its reactivity is due to presence of active epoxide moiety and thus it undergoes various transformation reactions leading to syntheses of chiral intermediates and biologically active products.

Manufacture
The chiral compound is manufactured by the reaction of tosyl chloride with S-glycidol. The resultant ester is treated with a strong base to obtain the desired product.

Synonym(2S)-(+)-Glycidyl tosylate
(S)-Glycidyl tosylate
CAS no.70987-78-9
EINECS no.417-210-7
Molecular formulaC10H12O4S
Molecular weight228.26
Structure
Applications
Enantioselective synthesis of 4-acetyl-3-hydroxymethyl-3,4-dihydro-2H-pyrido [3,3-b] oxazine
In synthesis of 1-O-hexadecyl-2-O-benzyl-sn-glycerol 3-O-p-toluenesuplhonte
As a reagent in production of chiral molecules and chiral intermediates for APIs such as:
# (S)-2-Oxiranylanisole
# S)-2-((3-Chlorophenoxy)methyl)oxirane
As building block for polymers and other materials
In synthesis of peptides, peptidomimetics, and other biological active substances
As an intermediate to synthesize neurochemicals

SPECIFICATIONS

TestUnitSpecification
AppearanceWhite to off-white crystalline powder
Specific rotation, (C=2.75 CHCl3)+17 to +19
LOD%Max 1.0
Melting point°C45.0 – 48.0
Assay by GC%Min 98.0
Enantiomeric excess by HPLCee%Min 99.0

STORAGE
2 to 8 °C

PACKING
25 kg drum

REACH Status
Not registered yet

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