INTRODUCTION
PTSA or pTsOH or Tosylic acid (TsOH) is white solid organic compound, that is soluble in water, alcohols, and other polar organic solvents. The group is known as the tosyl group and is often abbreviated as Ts or Tos. Most often, TsOH refers to the monohydrate, TsOH.H2O.
As with other sulfonic acids, TsOH is a strong organic acid. It is about one million times stronger than benzoic acid. It is one of the few strong acids that is solid and, hence, conveniently weighed. However, it is also available in solution form.
| Synonyms | 4-Methylbenzenesulfonic acid Tosic acid, Tosylic acid PTSA |
| CAS no. | 6192-52-5 (monohydrate) 104-15-4 (hydrous / solution) |
| EINECS no. | 203-180-0 |
| Molecular formula | C7H8SO3.H2O |
| Molecular weight | 190.22 |
| Structure |  |
APPLICATIONS
| PTSA is comparable in strength to mineral acids such as Sulfuric acid but are especially suitable for organic reactions where an inorganic, mineral acid could cause charring, oxidation, or an unwanted chemical reaction. |
| It is most useful as acid-catalyst reaction such as esterification / condensation / acetylation / polymerization / alkylation’s / hydrolysis / dehydration. |
| In Plasticizers industries mainly for DEP / DOP / DBP – as esterification catalyst. It is also used as curing agent for many resin system such as amino/phenolic/acrylic resins/resoles / epoxies / amino-Plastics and furniture lacquers. |
| As an anti-stress additive for electroplating baths additive, plastics, coatings, dyes, pharmaceutical intermediates, hydrotrope coupling agent and as a wetting agent. |
| Also applicable for use in food packaging adhesives. |
| As intermediate of dye chemistry. |
| As catalyst in Butyl Acrylate manufacturing. |
| As catalyst in Pharmaceutical industries for manufacturing of below products – Ciprofloxacin, Persantine, Naproxen, Doxycycline, Sulfamethoxazole. Also, for producing the intermediates of Amoxicillin, Cefadroxil. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance* | – | White crystalline powder |
| Assay on Monohydrate basis | % | Min 98 |
| P-isomer content in the active Material by a) HPLC method b) Others | % – | Min 92 Balance |
| Free Sulphuric Acid | % | Max 0.3 |
| Iron Content | ppm | Max 10.0 |
| Total Moisture | % | Max 11.50 |
| Melting Point | °C | Min 99 |
| Solubility in water | – | 100% soluble, clear solution |
*Note: The international specification of PTSA is white to off white to pink, though the material supplied would be white. However, as the product is highly hygroscopic – due to heat, sunlight and moisture the color may change from white to off white or pinkish in the course of time.
SPECIFICATIONS of 65% solution
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Pale yellow to amber colored liquid |
| Assay (on Anhydrous basis) | % | Min 65.0 |
| Free Sulphuric acid | % | Max 1.0 |
| Specific gravity (at 25°C) | – | 1.22 ± 0.02 |
STORAGE
The product is stored at ambient temperature.
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