INTRODUCTION
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure. The compound undergoes various reactions to form APIs and intermediates.
Manufacture
It is manufactured from N.N’-dicyclohexylurea either by using phosphorous oxychloride or phosphorous pentoxide.
| Synonyms | DCCD Carbodicyclohexylimide |
| CAS no. | 538-75-0 |
| EINECS no. | 208-704-1 |
| Molecular formula | C13H22N2 |
| Molecular weight | 206.33 |
| Structure |  |
Applications
| APIs: The diimide is used in the synthesis of APIs such as |
|---|
| Benexate HCl, an anti-ulcer drug |
| Angiotensin II, an anti-hypertensive drug and a peptide hormone |
| Docetaxel, an anti-cancer drug, also used in treatment of chronic heart failures |
| Intermediates: DCCD is used as a reagent in the synthesis of intermediates like |
|---|
| 2-Cyanopyridine-4-carboxaldehyde |
| Gly-7-amino-4-methylcoumarin |
| (S)-3-Aminoquinuclidine dihydrochloride |
| Others: |
|---|
| As dehydrating agent |
| As coupling agent in APIs and peptides |
| In synthesis of acid anhydrides, aldehydes, ketones, and isocyanates |
| In inversion and esterification of secondary alcohols |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Colorless to pale yellow liquid to semi-solid |
| Identification by GC | – | The retention time of the major peak in the chromatogram of the sample solution corresponds to that in the chromatogram of the standard solution |
| Solubility | – | Soluble in methanol and sparingly soluble in acetone |
| Purity by GC | % | Min 99.0 |
STORAGE
Stored at ambient temperature.
PACKING
35 kg UN approved Jerrycan.
REACH Status
Not registered yet.
ExSyn offers N,N’-dicyclohexylcarbodiimide on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Sodium Decane-1-Sulfonate is a surfactant with a long hydrophobic tail and hydrophilic sulfonate group, used to reduce surface tension and stabilize emulsions. It is commonly used in detergents, personal care products, and chemical formulations to enhance solubility and improve performance.
Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. It is a multifunctional Oil-in- Water Emulsifier that is a very versatile and multifunctional non-ionic surfactant used as fragrance builder and fragrance solubilizer,emulsifier in cosmetics and as pharmaceutical aid.
Trifluoroacetic anhydride is an organic liquid that belongs to the category of fluorochemicals. It is an anhydride of trifluoroacetic acid and has uses in APIs, intermediates, and agrochemicals. It is also a building block to introduce trifluoroacetyl group in organic moieties.
Benzene-d6 is a deuterated form of benzene, where hydrogen atoms are replaced by deuterium, making it ideal for use as a solvent in NMR spectroscopy. It is widely employed in chemical, pharmaceutical, and environmental research for isotopic labeling and reaction mechanism studies.
Pyridinium tribromide, an organic solid from the category of heterocyclic halides, is a highly efficient and selective bromination agent in organic syntheses. It is also used in production of APIs and intermediates.
Pyrophosphoryl Tetrachloride is a colorless fuming corrosive liquid .It consists of a pyrophosphate (a molecule with a P-O-P bond) group, where one phosphorus atom is bonded to four chlorine atoms and the other is bonded to three chlorine atoms.
It is a reactive chemical compound and should be handled with care. Commonly used in the synthesis of other phosphorus-containing compounds and as a chlorinating agent in organic chemistry
Trifluoroacetic acid (TFA) is widely used in organic synthesis as a solvent, catalyst, and reagent, owing to its reactivity and stability under adverse conditions. It is considered as one of the most economical fluorinated building blocks.
Acryloyl chloride is an organic liquid from the class of acid chlorides. It is a toxic and lachrymatic chemical that has a variety of applications in APIs, intermediates and polymers.
Triton X-100 is a widely used non-ionic surfactant and emulsifier that effectively solubilizes powders and proteins. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.