INTRODUCTION

N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure. The compound undergoes various reactions to form APIs and intermediates.

Manufacture
It is manufactured from N.N’-dicyclohexylurea either by using phosphorous oxychloride or phosphorous pentoxide.

SynonymsDCCD
Carbodicyclohexylimide
CAS no.538-75-0
EINECS no.208-704-1
Molecular formulaC13H22N2
Molecular weight206.33
Structure

Applications

APIs: The diimide is used in the synthesis of APIs such as
Benexate HCl, an anti-ulcer drug
Angiotensin II, an anti-hypertensive drug and a peptide hormone
Docetaxel, an anti-cancer drug, also used in treatment of chronic heart failures
Intermediates: DCCD is used as a reagent in the synthesis of intermediates like
2-Cyanopyridine-4-carboxaldehyde
Gly-7-amino-4-methylcoumarin
(S)-3-Aminoquinuclidine dihydrochloride
Others:
As dehydrating agent
As coupling agent in APIs and peptides
In synthesis of acid anhydrides, aldehydes, ketones, and isocyanates
In inversion and esterification of secondary alcohols

SPECIFICATIONS

TestUnitSpecification
AppearanceColorless to pale yellow liquid to semi-solid
Identification by GCThe retention time of the major peak in the chromatogram of the sample solution corresponds to that in the chromatogram of the standard solution
SolubilitySoluble in methanol and sparingly soluble in acetone
Purity by GC%Min 99.0

STORAGE
Stored at ambient temperature.

PACKING
35 kg UN approved Jerrycan.

REACH Status
Not registered yet.

ExSyn offers N,N’-dicyclohexylcarbodiimide on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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