INTRODUCTION

N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure. The compound undergoes various reactions to form APIs and intermediates.

Manufacture
It is manufactured from N.N’-dicyclohexylurea either by using phosphorous oxychloride or phosphorous pentoxide.

SynonymsDCCD
Carbodicyclohexylimide
CAS no.538-75-0
EINECS no.208-704-1
Molecular formulaC13H22N2
Molecular weight206.33
Structure

Applications

APIs: The diimide is used in the synthesis of APIs such as
Benexate HCl, an anti-ulcer drug
Angiotensin II, an anti-hypertensive drug and a peptide hormone
Docetaxel, an anti-cancer drug, also used in treatment of chronic heart failures
Intermediates: DCCD is used as a reagent in the synthesis of intermediates like
2-Cyanopyridine-4-carboxaldehyde
Gly-7-amino-4-methylcoumarin
(S)-3-Aminoquinuclidine dihydrochloride
Others:
As dehydrating agent
As coupling agent in APIs and peptides
In synthesis of acid anhydrides, aldehydes, ketones, and isocyanates
In inversion and esterification of secondary alcohols

SPECIFICATIONS

TestUnitSpecification
AppearanceColorless to pale yellow liquid to semi-solid
Identification by GCThe retention time of the major peak in the chromatogram of the sample solution corresponds to that in the chromatogram of the standard solution
SolubilitySoluble in methanol and sparingly soluble in acetone
Purity by GC%Min 99.0

STORAGE
Stored at ambient temperature.

PACKING
35 kg UN approved Jerrycan.

REACH Status
Not registered yet.

ExSyn offers N,N’-dicyclohexylcarbodiimide on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

More Products
In focus: L – Carnitine Hydrochloride
Products in focus · 29/04/2025

L-carnitine Hydrochloride is a water soluble, stable salt form of L- Carnitine. It is a naturally occurring amino acid derivative.  It is often used as a dietary  supplement due to its role in energy production and fat metabolism.

READ MORE
In focus: Dimenhydrinate USP
Products in focus · 22/04/2025

Dimenhydrinate is an antihistamine drug commonly used to prevent and treat motion sickness, nausea, and vertigo. It is a combination of diphenhydramine and 8-chlorotheophylline, where the latter reduces the sedative effects of diphenhydramine. It is available in tablet, liquid, and injectable forms under various brand names.

READ MORE
In focus: o-Nitrophenyl Disulfide
Products in focus · 15/04/2025

o-Nitrophenyl Disulfide is a chemical compound used in organic chemistry and biochemistry. It is a disulfide derivative where two o-nitrophenyl groups are connected by a disulfide bond (-S-S-) It is used in various organic synthesis reactions, as a reagent in the preparation of thiol-reactive compounds, in pharmaceutical research and laboratory applications.

READ MORE
In focus: Tetrasodium Pyrophosphate, Anhydrous
Products in focus · 08/04/2025

Tetrasodium pyrophosphate (TSPP) anhydrous is a white, crystalline or granular inorganic compound, soluble in water but insoluble in alcohol. TSPP is widely used in food, industrial, and cleaning applications due to its sequestrant, dispersing, buffering, and emulsifying properties.

READ MORE
In focus: Potassium Sodium Tartrate
Products in focus · 01/04/2025

Potassium sodium tartrate commonly known as Rochelle salt, is a double salt of tartaric acid. It is a white crystalline solid that is highly soluble in water. This compound is well known for its piezoelectric properties and has been historically used in various scientific and industrial applications.

READ MORE
In focus: Tert – Amyl Alcohol
Products in focus · 25/03/2025

Tert-Amyl Alcohol (TAA) also known as 2-Methyl-2-butanol, is a branched-chain alcohol. It is a colorless, flammable liquid with a mild alcoholic odor and moderate water solubility. Due to its unique structural properties, it is widely used as basic organic chemical in synthetic fragrances, pharmaceuticals and pigment industries.

READ MORE
In focus: Lithium Orotate, Monohydrate
Products in focus · 18/03/2025

Lithium orotate is a compound consisting of lithium, an alkali metal, and orotic acid, a natural substance involved in nucleic acid metabolism. It is a popular dietary supplement due to its potential neuroprotective and mood-stabilizing effects.

READ MORE
In focus: 3-Quinuclidinone Hydrochloride
Products in focus · 11/03/2025

Quinuclidinone Hydrochloride is a derivative of bicyclic amine quinuclidine. The hydrochloride form of quinuclidinone is the salt form, often used for its stability in different reactions. Quinuclidinone Hydrochloride is typically used as an intermediate in the synthesis of various pharmaceuticals and other chemical products.

READ MORE
In focus: Potassium Benzoate FCC
Products in focus · 04/03/2025

Potassium benzoate (E212), the potassium salt of benzoic acid, is a food preservative used to prevent the growth of mold, yeast and some bacteria. It works best in low-pH products, below 4.5, where it exists as benzoic acid.

READ MORE