INTRODUCTION

L-Alpha glycerylphosphorylcholine (alpha-GPC or choline alfoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerol-1-phosphate is used to support cellular membranes.

Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. It is currently the best cholinergic for increasing plasma and brain choline levels.

Manufacture
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well as from purified sunflower lecithin.

SynonymsCholine glycerophosphate
L-α-Phosphatidylcholine
CAS no.28319-77-9
EINECS no.248-962-2
Molecular formulaC8H20NO6P
Molecular weight257.22
Structure

Applications

Alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.
Alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA).
Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter.

SPECIFICATIONS

TestUnitSpecification
AppearanceWhite to off white hygroscopic powder
Identification – TLCStandard solution and test solution same spot, RF
Specific Optical Rotation-2.4° ~ 2.8°
Water content%NMT 2.00
pH4.5 to 7.0
Assay%98.50 – 100.00
Chemical Tests
Sulfate%NMT 0.02
Chloride%NMT 0.02
Related substanceSpot not bigger than standard solution spot
Residual solvent%NMT 0.5
Heavy metalsppmNMT 10.00

STORAGE
Store in an airtight and light resistant container, away from moisture.

PACKING
5 kg HDPE drum.

REGISTRATION / CERTIFICATION
ISO, FSSAI, HACCP, HALAL, KOSHER & GMP certified.

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