L-Alpha glycerylphosphorylcholine (alpha-GPC or choline alfoscerate) is a choline-containing phospholipid. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerol-1-phosphate is used to support cellular membranes.
Alpha-GPC appears to easily cross the blood-brain barrier and is rapidly absorbed. It is currently the best cholinergic for increasing plasma and brain choline levels.
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well as from purified sunflower lecithin.
|Alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.|
|Alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA).|
|Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter.|
|Appearance||–||White to off white hygroscopic powder|
|Identification – TLC||–||Standard solution and test solution same spot, RF|
|Specific Optical Rotation||–||-2.4° ~ 2.8°|
|Water content||%||NMT 2.00|
|pH||–||4.5 to 7.0|
|Assay||%||98.50 – 100.00|
|Related substance||–||Spot not bigger than standard solution spot|
|Residual solvent||%||NMT 0.5|
|Heavy metals||ppm||NMT 10.00|
Store in an airtight and light resistant container, away from moisture.
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