INTRODUCTION
4-(Dimethylamino)pyridine (DMAP) is an efficient and versatile acylation catalyst. Besides, it find uses in other chemical reactions as well as in production of APIs, agrochemicals, and intermediates.
Manufacture
The product is commercially manufactured by methylation of 4-pyridinamine. Alternatively, it is produced by ammonolysis of 4-hydroxypyridine followed by the methylation.
| Synonyms | ɣ-(Dimethylamino)pyridine N,N-Dimethyl-4-pyridinamine |
| CAS no. | 1122-58-3 |
| EINECS no. | 214-353-5 |
| Molecular formula | C7H10N2 |
| Molecular weight | 122.17 |
| Structure |  |
Applications in APIs
| DMAP is consumed in production of APIs such as: |
|---|
| Abacavir (nucleoside reverse transcriptase inhibitor) |
| Lamivudine (anti-HIV) |
| Zidovudine (anti-HIV) |
| Ivacaftor (Cystic Fibrosis Treatment) |
| Montelukast (anti-Asthma) |
| Docetaxel (anti-Cancer) |
| Paclitaxel (anti-Caner, antineoplastic) |
| Rosuvastatin (anti-Cholesterol) |
| Alfentanil (Analgesic) |
| Carfentanil (Analgesic) |
| Cladribine (anti-Leukemia) |
Applications in Agrochemicals
| The dimethylated pyridine is used to produce agrochemicals: |
|---|
| Chlorpyriphos (Insecticide) |
| Clethodim (Herbicide) |
| Sethoxidim (Herbicide) |
Applications in Intermediates
| DMAP is also a KRM for the synthesis of the following intermediates: |
|---|
| N,N-Dimethyl-1-(2,4,6-trinitrophenyl)pyridin-1-ium-4-amine chloride |
| N,N-Dimethylpiperidin-4-amine |
Other Uses
It also acts as a catalyst in some alkylation, etherification, and esterification reactions.
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off-white crystalline solid |
| Identifications by GC | – | Retention time of the major peak matches with that of the reference standard |
| Melting range | °C | 111-114 |
| Moisture by KF | % w/w | Max 0.1 |
| Purity by GC | % | Min 99.00 |
| Assay by chemical method | % | Min 99.00 |
STORAGE
The product is stored at ambient temperature.
PACKING
25 kg fibre drum.
REACH Status
DMAP offered by ExSyn is registered under EU REACH regulations.
ExSyn offers DMAP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
1-(Difluoromethyl)-4-nitro-1H-pyrazole is a difluoromethyl aromatic compound with an active nitro group for reduction. It is used as an organic synthesis key starting material and intermediate in APIs.
1-Bromohexane is an organic liquid belonging to the category of alkyl bromides or bromoalkanes. Its reactivity is due to presence of bromine in the allylic position. Apart from being a useful solvent in organic synthesis, it is used in synthesis of various intermediates.
Valeryl chloride is an organic liquid belonging to the category – acid chloride. It is a versatile reagent in organic syntheses leading to its diverse applications such as synthesis of enzyme inhibitors, production of APIs, intermediates, and agrochemicals.
2-Chloroethylamine hydrochloride is a colourless to off-white solid. It consists of an alkylamine attached to a Chlorine atom. It is a member of the Chloroalkylamines. It is a highly corrosive material to both skin and metals thus it must be handled with extreme care.
Thiophosgene is an organic liquid with a heterogeneous composition. The molecule is a reactive electrophile leading to its applications in APIs, intermediates, and agrochemicals, amongst others.
N.N’-Dicyclohexylcarbodiimide, acronymed as DCCD by chemists, is a versatile reagent in organic syntheses. Its reactivity is due to the presence of carbodiimide group in its structure.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Bakuchiol is known as Vegan Retinol as it has ability to improve uneven skin tone by reducing the appearance of dark spots and pigmentation. It is best in class of anti-aging and anti-wrinkles effect.