INTRODUCTION

4-(Dimethylamino)pyridine (DMAP) is an efficient and versatile acylation catalyst. Besides, it find uses in other chemical reactions as well as in production of APIs, agrochemicals, and intermediates.

Manufacture
The product is commercially manufactured by methylation of 4-pyridinamine. Alternatively, it is produced by ammonolysis of 4-hydroxypyridine followed by the methylation.

Synonymsɣ-(Dimethylamino)pyridine
N,N-Dimethyl-4-pyridinamine
CAS no.1122-58-3
EINECS no.214-353-5
Molecular formulaC7H10N2
Molecular weight122.17
Structure

Applications in APIs

DMAP is consumed in production of APIs such as:
Abacavir (nucleoside reverse transcriptase inhibitor)
Lamivudine (anti-HIV)
Zidovudine (anti-HIV)
Ivacaftor (Cystic Fibrosis Treatment)
Montelukast (anti-Asthma)
Docetaxel (anti-Cancer)
Paclitaxel (anti-Caner, antineoplastic)
Rosuvastatin (anti-Cholesterol)
Alfentanil (Analgesic)
Carfentanil (Analgesic)
Cladribine (anti-Leukemia)

Applications in Agrochemicals

The dimethylated pyridine is used to produce agrochemicals:
Chlorpyriphos (Insecticide)
Clethodim (Herbicide)
Sethoxidim (Herbicide)

Applications in Intermediates

DMAP is also a KRM for the synthesis of the following intermediates:
N,N-Dimethyl-1-(2,4,6-trinitrophenyl)pyridin-1-ium-4-amine chloride
N,N-Dimethylpiperidin-4-amine

Other Uses
It also acts as a catalyst in some alkylation, etherification, and esterification reactions.

SPECIFICATIONS

TestUnitSpecification
AppearanceWhite to off-white crystalline solid
Identifications by GCRetention time of the major peak matches with that of the reference standard
Melting range°C111-114
Moisture by KF% w/wMax 0.1
Purity by GC%Min 99.00
Assay by chemical method%Min 99.00

STORAGE
The product is stored at ambient temperature.

PACKING
25 kg fibre drum.

REACH Status
DMAP offered by ExSyn is registered under EU REACH regulations.

ExSyn offers DMAP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.

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