INTRODUCTION
Indole-3-carbinol is a colorless powder with a characteristic odor.
The product finds uses in various fields by virtue of the indole ring, which is active and mainly imparts medicinal properties to the molecule. It is also an important dietary supplement.
Manufacture
Biologically, it is produced by enzyme-catalysed hydrolysis of glucosinolate, abundantly found in cabbage, cauliflower, and other vegetables of Bressica family.
Synthetically and commercially, it is product of indole-3-acetic acid reduction.
| Synonyms | Indole-3-methanol |
| CAS no. | 700-06-1 |
| EINECS no. | 211-836-2 |
| Molecular formula | C9H9NO |
| Molecular weight | 147.17 |
| Structure |  |
Medicinal Uses
Indiole-3-carbinol is cited to have medicinal properties and is subject of many clinical trials. It is applied in medicines to:
| prevent breast cancer |
| cure obesity |
| lower risk of prostate cancer recurrence |
Nutritional Uses
| As an antioxidant |
| Dietary supplement |
Value-added Intermediates
Indole-3-carbinol is used as a KRM to make various intermediates for pharmaceutical applications, such as:
| Indole-3-carboxylic acid |
| Indole-3-carboxaldehyde |
| Indolo[3,2b]carbazole |
| 3,3’-Diindolylmethane |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to red powder |
| Identification | – | Should give positive reaction |
| Melting range | °C | 97-100 |
| Loss on drying | % | Max 2.0 |
| Residue on ignition | % | Max 0.1 |
| Residual solvents | – | Not detected |
| Assay by HPLC | % | Min 99.0 |
| Total heavy metals | ppm | Max 10.0 |
| Lead | ppm | Max 0.5 |
| Arsenic | ppm | Max 0.5 |
| Mercury | ppm | Max 0.1 |
| Cadmium | ppm | Max 0.5 |
| Particle size | ||
| 40 mesh | % | 100 |
| 80 mesh | % | 80 |
| 120 mesh | % | 60 |
| Microbial Test | ||
| Total plate count | cfu/g | Max 1000 |
| Yeast and mold | cfu/g | Max 100 |
| Salmonella | – | Should be absent |
| E Coli | – | Should be absent |
| Staphylococcus | – | Should be absent |
| Pseudomonas | – | Should be absent |
CERTIFICATION
The product is offered from NSF-GMP facility supported by a DMF for Nutraceutical application.
STORAGE
Recommended storage temperature is 2° to 8°C
PACKING
10 kg bag in HDPE Drum
ExSyn offers indole-3-carbinol on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Sodium Decane-1-Sulfonate is a surfactant with a long hydrophobic tail and hydrophilic sulfonate group, used to reduce surface tension and stabilize emulsions. It is commonly used in detergents, personal care products, and chemical formulations to enhance solubility and improve performance.
Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. It is a multifunctional Oil-in- Water Emulsifier that is a very versatile and multifunctional non-ionic surfactant used as fragrance builder and fragrance solubilizer,emulsifier in cosmetics and as pharmaceutical aid.
Trifluoroacetic anhydride is an organic liquid that belongs to the category of fluorochemicals. It is an anhydride of trifluoroacetic acid and has uses in APIs, intermediates, and agrochemicals. It is also a building block to introduce trifluoroacetyl group in organic moieties.
Benzene-d6 is a deuterated form of benzene, where hydrogen atoms are replaced by deuterium, making it ideal for use as a solvent in NMR spectroscopy. It is widely employed in chemical, pharmaceutical, and environmental research for isotopic labeling and reaction mechanism studies.
Pyridinium tribromide, an organic solid from the category of heterocyclic halides, is a highly efficient and selective bromination agent in organic syntheses. It is also used in production of APIs and intermediates.
Pyrophosphoryl Tetrachloride is a colorless fuming corrosive liquid .It consists of a pyrophosphate (a molecule with a P-O-P bond) group, where one phosphorus atom is bonded to four chlorine atoms and the other is bonded to three chlorine atoms.
It is a reactive chemical compound and should be handled with care. Commonly used in the synthesis of other phosphorus-containing compounds and as a chlorinating agent in organic chemistry
Trifluoroacetic acid (TFA) is widely used in organic synthesis as a solvent, catalyst, and reagent, owing to its reactivity and stability under adverse conditions. It is considered as one of the most economical fluorinated building blocks.
Acryloyl chloride is an organic liquid from the class of acid chlorides. It is a toxic and lachrymatic chemical that has a variety of applications in APIs, intermediates and polymers.
Triton X-100 is a widely used non-ionic surfactant and emulsifier that effectively solubilizes powders and proteins. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.