INTRODUCTION
Indole-3-carbinol is a colorless powder with a characteristic odor.
The product finds uses in various fields by virtue of the indole ring, which is active and mainly imparts medicinal properties to the molecule. It is also an important dietary supplement.
Manufacture
Biologically, it is produced by enzyme-catalysed hydrolysis of glucosinolate, abundantly found in cabbage, cauliflower, and other vegetables of Bressica family.
Synthetically and commercially, it is product of indole-3-acetic acid reduction.
| Synonyms | Indole-3-methanol |
| CAS no. | 700-06-1 |
| EINECS no. | 211-836-2 |
| Molecular formula | C9H9NO |
| Molecular weight | 147.17 |
| Structure |  |
Medicinal Uses
Indiole-3-carbinol is cited to have medicinal properties and is subject of many clinical trials. It is applied in medicines to:
| prevent breast cancer |
| cure obesity |
| lower risk of prostate cancer recurrence |
Nutritional Uses
| As an antioxidant |
| Dietary supplement |
Value-added Intermediates
Indole-3-carbinol is used as a KRM to make various intermediates for pharmaceutical applications, such as:
| Indole-3-carboxylic acid |
| Indole-3-carboxaldehyde |
| Indolo[3,2b]carbazole |
| 3,3’-Diindolylmethane |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to red powder |
| Identification | – | Should give positive reaction |
| Melting range | °C | 97-100 |
| Loss on drying | % | Max 2.0 |
| Residue on ignition | % | Max 0.1 |
| Residual solvents | – | Not detected |
| Assay by HPLC | % | Min 99.0 |
| Total heavy metals | ppm | Max 10.0 |
| Lead | ppm | Max 0.5 |
| Arsenic | ppm | Max 0.5 |
| Mercury | ppm | Max 0.1 |
| Cadmium | ppm | Max 0.5 |
| Particle size | ||
| 40 mesh | % | 100 |
| 80 mesh | % | 80 |
| 120 mesh | % | 60 |
| Microbial Test | ||
| Total plate count | cfu/g | Max 1000 |
| Yeast and mold | cfu/g | Max 100 |
| Salmonella | – | Should be absent |
| E Coli | – | Should be absent |
| Staphylococcus | – | Should be absent |
| Pseudomonas | – | Should be absent |
CERTIFICATION
The product is offered from NSF-GMP facility supported by a DMF for Nutraceutical application.
STORAGE
Recommended storage temperature is 2° to 8°C
PACKING
10 kg bag in HDPE Drum
ExSyn offers indole-3-carbinol on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
L-carnitine Hydrochloride is a water soluble, stable salt form of L- Carnitine. It is a naturally occurring amino acid derivative. It is often used as a dietary supplement due to its role in energy production and fat metabolism.
Dimenhydrinate is an antihistamine drug commonly used to prevent and treat motion sickness, nausea, and vertigo. It is a combination of diphenhydramine and 8-chlorotheophylline, where the latter reduces the sedative effects of diphenhydramine. It is available in tablet, liquid, and injectable forms under various brand names.
o-Nitrophenyl Disulfide is a chemical compound used in organic chemistry and biochemistry. It is a disulfide derivative where two o-nitrophenyl groups are connected by a disulfide bond (-S-S-) It is used in various organic synthesis reactions, as a reagent in the preparation of thiol-reactive compounds, in pharmaceutical research and laboratory applications.
Tetrasodium pyrophosphate (TSPP) anhydrous is a white, crystalline or granular inorganic compound, soluble in water but insoluble in alcohol. TSPP is widely used in food, industrial, and cleaning applications due to its sequestrant, dispersing, buffering, and emulsifying properties.
Potassium sodium tartrate commonly known as Rochelle salt, is a double salt of tartaric acid. It is a white crystalline solid that is highly soluble in water. This compound is well known for its piezoelectric properties and has been historically used in various scientific and industrial applications.
Tert-Amyl Alcohol (TAA) also known as 2-Methyl-2-butanol, is a branched-chain alcohol. It is a colorless, flammable liquid with a mild alcoholic odor and moderate water solubility. Due to its unique structural properties, it is widely used as basic organic chemical in synthetic fragrances, pharmaceuticals and pigment industries.
Lithium orotate is a compound consisting of lithium, an alkali metal, and orotic acid, a natural substance involved in nucleic acid metabolism. It is a popular dietary supplement due to its potential neuroprotective and mood-stabilizing effects.
Quinuclidinone Hydrochloride is a derivative of bicyclic amine quinuclidine. The hydrochloride form of quinuclidinone is the salt form, often used for its stability in different reactions. Quinuclidinone Hydrochloride is typically used as an intermediate in the synthesis of various pharmaceuticals and other chemical products.
Potassium benzoate (E212), the potassium salt of benzoic acid, is a food preservative used to prevent the growth of mold, yeast and some bacteria. It works best in low-pH products, below 4.5, where it exists as benzoic acid.