INTRODUCTION
Colchicine belongs to a class of drugs called Uricosuric agents.
It is an alkaloid used in the symptomatic relief of pain in attacks of gouty arthritis, pseudogout, sarcodial arthritis, calcific tendinitis and to treat the inflammatory symptoms of Familial Mediterranean Fever.
It appears as odourless or nearly odourless pale yellow needles or powder that darkens on exposure to light.
Manufacture
It is derived from the bulb-like corms of the Colchicum autumnale plant, also known as autumn crocus.
Synonyms | N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]-acetamide |
CAS no. | 64-86-8 |
EINECS no. | 200-598-5 |
Molecular formula | C22H25NO6 |
Molecular weight | 399.44 |
Structure | ![]() |
Applications
Gout and Pseudogout | Colchicine has been known as a treatment for gout for several millenia. It is also recommended for the treatment of acute flares, as well as flare prophylaxis, in patients with pseudogout or calcium pyrophosphate crystal arthritis. |
Familial Mediterranean Fever | Colchicine has been the treatment of choice for Familial Mediterranean Fever (FMF) a hereditary autoinflammatory condition since the 1970’s. |
Uses in Dermatology | Colchicine has been reported to be an efficacious and well-tolerated treatment for numerous dermatologic diseases. Behçet’s disease, epidermolysis bullosa acquisita, leukocytocastic vasculitis, Sweet’s syndrome and recurrent apthous stomatitis are some of the few dermatologic diseases in which treatment with colchicine has been studied. |
New Potential Indications | The potential uses of colchicine have broadened significantly over the last few years as new studies have emerged demonstrating novel applications within oncology, immunology, cardiology, and dermatology. |
SPECIFICATIONS – EP/BP
Test | Unit | Specification |
---|---|---|
Appearance | – | Yellowish-White, amorphous or crystalline powder |
Solubility | – | Very soluble in wáter, rapidly re-crystallizing from concentrated solutions as the sesquihydrate, freely soluble in Ethanol (96%), practically insoluble in Cyclohexane |
Identification 1. By UV 2. By IR 3. By Chemical 4. By Chemical | – – – – | The ratio of absorbance measured at 243 nm to that measured 350 nm is 1.7 to 1.9 The IR absorption spectrum of the preparation of the test specimen and working standard, exhibits maxima only at the same wave lengths The organic layer is greenish-yellow A brownish-red colour develops |
Appearance of solution | – | Solution S is clear (2.2.1) and not more intensely coloured than reference solution GY3 (2.2.2, Method II) |
Acidity or Alkalinity | – | Either the solution does not change colour or it become green. Not more tan 0.1 ml of 0.01 M Sodium hydroxide is required to change the colour of the indicator to blue |
Specific optical rotation | – | -250° to -235°, calculated on the anhydrous substance |
Related substances (by HPLC) 1. Impurity ‘A’ 2. Impurity ‘G’ 3. Impurity ‘E’ 4. Unspecified impurities 5. Total impurities | % % % % % | Max 3.0 Max 0.25 Max 0.20 Max 0.10 Max 4.0 |
Impurity F | % | Max 0.2 |
Ethyl acetate (by GC) | % | Max 6.0 |
Water content (by KF) | % | Max 2.0% determined on 0.500 gm |
Sulphated ash | – | Max 0.1% determined on 0.500 gm |
Residual solvents (by HSGC) 1. Methanol 2. Acetone 3. Methylene Dichloride 4. Chloroform | ppm ppm ppm ppm | NMT 3000 NMT 5000 NMT 600 NMT 500 |
Assay (Potentiometer) | % | 97.0 to 102.0 |
STORAGE
Store in a dry and well-ventilated area.
PACKING
1 kg aluminum foil in steel container.
REGISTRATION / CERTIFICATION
ISO, WHO-GMP, Written Confirmation (WC), DMF as per EP/BP/USP & Certificate of Suitability (CEP) to European monograph.
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
2-(tert-Butyl amino)ethyl methacrylate (TBAEMA) is a functional methacrylate monomer that contains a secondary amine group and a hydrophobic tert-butyl moiety, giving it excellent versatility in pH-responsive and adhesion-enhancing polymer systems.
It is valued in printing ink formulations for its ability to enhance adhesion, flexibility, and surface interaction.
Commonly known as potassium bis(fluorosulfonyl)imide (KFSI), the compound has a three-carbon backbone bearing six fluorine atoms and two sulfonimide (-SO₂F) groups. The molecule’s architecture lends it both high chemical stability and useful reactivity. Because of its excellent ionic conductivity and thermal / electrochemical stability, it finds use in advanced electrolyte formulations—for example in lithium-ion and next-generation batteries, in ionic liquids, and in other electrochemical systems.
Colchicine is a naturally occurring alkaloid obtained primarily from the autumn crocus (Colchicum autumnale) and related species. It has been used in medicine for centuries, especially for the treatment of gout and Familial Mediterranean Fever. In modern medicine, Colchicine is valued also in conditions like pericarditis, Behçet’s disease, and certain dermatological and cardiac disorders.
1-Butylimidazole is a versatile organic heterocyclic compound belonging to the imidazole family, where a butyl group (–CH₂–CH₂–CH₂–CH₃) is attached to the nitrogen atom at the 1-position of the imidazole ring. Its applications span organic synthesis, materials science, and bioactive compound development due to its tunable physicochemical properties and structural versatility.
Atropine sulfate monohydrate is a chemical compound, specifically a salt of atropine and sulfuric acid, with one water molecule (monohydrate) attached. It is commonly used as a medication and in research due to its anticholinergic properties, meaning it blocks the effects of acetylcholine at muscarinic receptors.
4-Aminobenzoic acid, commonly abbreviated as PABA, is an aromatic amine and carboxylic acid compound. It consists of a benzene ring substituted with an amino group (–NH₂) in the para position to a carboxylic acid group (–COOH).
2-Amino-5-Nitrophenol (5-NAP) is an organic compound with the molecular formula C₆H₆N₂O₃. It is a substituted phenol with both an amino group (-NH₂) and a nitro group (-NO₂) attached to a benzene ring, along with a hydroxyl group (-OH).
Pongamol is a naturally occurring flavonoid primarily extracted from the seeds and leaves of the Pongamia pinnata tree (also known as Karanja tree), native to South and Southeast Asia. It is a cream-colored compound that belongs to the flavonoid family and is known for its antioxidant, anti-inflammatory, antimicrobial, and pesticidal properties. It is one of the key bioactive constituents of Pongamia oil.
Biobased Ethyl Acetate is an environmentally friendly solvent made from renewable sources like bioethanol extracted from sugarcane, corn, and other forms of biomass. Unlike traditional ethyl acetate, which is typically derived from fossil fuels, this green alternative shares the same chemical structure (C₄H₈O₂) and functional performance—offering comparable versatility with a significantly lower environmental footprint.